Psoralea Corylifolia

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Psoralea Corylifolia

Other Names : Babchi, Bu Gu Zhi, Babechi, Kushtanashini, Fountain bush, West Indian Satinwood, Somaraji, Bavachi, Habuch, Bakuchi, Bavanchalu, Ravoli
Bakuchi is an Ayurvedic herb and Bu Gu Zhi a widely used medical plant in China It belongs to Fabaceae family.

Special Precautions of Psoralea Corylifolia

P. corylifolia has been implicated in at least one case of severe hepatotoxicity in a 64-year-old woman who self-medicated with a variety of Aryuvedic herbs for her vitiligo. The authors identify psoralens as "the primary candidate causing the hepatotoxic reaction".

Benefits and uses of Psoralea Corylifolia are

P. corylifolia extract contains a number of chemical compounds including flavonoids (neobavaisoflavone, isobavachalcone, bavachalcone, bavachinin, bavachin, corylin, corylifol, corylifolin and 6-prenylnaringenin), coumarins (psoralidin, psoralen, isopsoralen and angelicin) and meroterpenes (bakuchiol and 3-hydroxybakuchiol).

  • efficacy against skin diseases including leucoderma
  • menopause to fight signs and symptoms of estrogen deficiency. There is limited evidence in humans currently, so most conclusions are based upon animal models and in vitro research.
  • some promise for the purpose of bone regeneration in several rat models of menopause, and this appears to be traceable to several different molecules; the class of prenylated isoflavones appears to enhance bone cell differentiation and said rat studies have confirmed an increase in bone mass.
  • Cancer : Psoralidin has shown activity in vitro against gastric, colon, prostate, and breast cancer lines. P. corylifolia L. significantly inhibits proliferation of sensitive and MDR cancer cells in vitro, psoralen and isopsoralen are responsible for the anticancer activity.
  • Bu Gu Zhi in traditional Chinese medicine (TCM) to tonify the kidneys, particularly kidney yang and essence. It is used for helping the healing of bone fractures, for lower back and knee pain, impotence, bed wetting, hair loss, and vitiligo.
  • An extract of the plant's fruit Fructus psoraleæ has been shown to act as a norepinephrine-dopamine reuptake inhibitor in vitro.
  • Extracts obtained from the seeds of P. corylifolia have been shown to inhibit mitochondrial complex I in vitro and may therefore increase susceptibility to oxidative stress.
  • Psoralea has interesting mechanisms in regards to inducing apoptosis in cancer cells (the anti-cancer effects). Psoralea appears to increase the amount of death receptors (TRAILR2/DR5) on the cell surface and enhance signalling via the immune system, particulary TNF-α and other proteins in the TRAIL family.

References

https://www.hindawi.com/journals/ecam/2011/363052/