Guggul

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Other Names: Devadhupa, Balsamodendrum wightii, Balsamodendrum mukul, Commiphora mukul, Commiphora wightii, Gomme Guggul, Gomme-Résine de Guggul, Guggal, Guggul Gum Resin, Guggul Lipids, Guggulipid, Guggulipide, Guggulu, Guggulu Suddha, Guggulsterone, Guggulstérone, Guggulsterones, Guggulstérones, Guglipid, Gugulipid, Gum Guggal, Gum Guggulu, Indian Bdellium, Indian Bdellium-Tree, Koushika, Mukul Myrrh Tree, Palankasha, Yogaraj Guggul Gum Resin.
A yellowish resin secreted by the mukul myrrh tree (Commiphora mukul), guggul has been used for thousands of years in ayurveda.
See also : Myrrh

Special Precautions of Guggul

  • Guggul is POSSIBLY SAFE for most people. It has been used safely in clinical trials for up to 24 weeks. Some evidence also suggests that long-term use up to 75 weeks may be safe.
  • It can cause side effects such as stomach upset, headaches, nausea, vomiting, loose stools, diarrhea, belching, and hiccups. Guggul can also cause allergic reactions such as rash and itching. Guggul can also cause skin rash and itching that is not related to allergy. These adverse reactions are more common with higher doses, such as 6000 mg per day.
  • Pregnancy and breast-feeding: Guggul is LIKELY UNSAFE during pregnancy. It seems to encourage menstrual flow and stimulates the uterus, so some researchers worry that it might endanger the pregnancy. Not enough is known about the safety of using guggul during breast-feeding. Don’t use guggul if you are pregnant or breast-feeding.
  • Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Guggul might act like estrogen in the body. If you have any condition that might be made worse by exposure to estrogen, don’t use guggul.
  • Underactive or overactive thyroid (hypothyroidism or hyperthyroidism): Guggul might interfere with treatment for these conditions. If you have a thyroid condition, don’t use guggul without your healthcare provider’s supervision.
  • Surgery: Guggul might increase the risk of bleeding during and after surgery. Stop using guggul at least 2 weeks before a scheduled surgery.
  • Estrogens interacts with GUGGUL : Large amounts of guggul might theoretically increase the side effects of estrogen.
  • Birth control pills (Contraceptive drugs) interacts with GUGGUL
  • Diltiazem (Cardizem, Dilacor, Tiazac) interacts with GUGGUL
  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with GUGGUL
  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with GUGGUL
  • Propranolol (Inderal) interacts with GUGGUL
  • Tamoxifen (Nolvadex) interacts with GUGGUL
  • Thyroid hormone interacts with GUGGUL

The benefits of Guggul are

This ancient herb contains several bioactive components that fight inflammation. Two highly effective compounds are gugglesterone and myrrhanol A.

  • Treating some types of acne. Guggul seems to work about as well as the antibiotic tetracycline in the treatment of nodulocystic acne. Both treatments decrease pain, swelling , and redness (inflammation), and the number of acne outbreaks.
  • Lowering cholesterol and triglycerides in the blood of people eating a Western diet. Interestingly, guggul does seem to work in Indian populations, who eat a different type of diet. Among this group, guggul seems to lower total cholesterol, “bad cholesterol” (LDL cholesterol), and other blood fats called triglycerides.
  • Arthritis. Preliminary clinical evidence suggests that taking 500 mg of guggul (containing 3.5% guggulsterones) three times daily might improve arthritis pain.
  • Other research shows that guggul extract may help reduce symptoms of osteoarthritis (OA) of the knee.
  • Weight loss. There is some clinical evidence that guggul in combination with phosphate, hydroxycitric acid, and L-tyrosine plus exercise and a low-calorie diet might result in modest weight loss. However, a separate study of a standardized guggul extract generally used for lowering cholesterol found that doses of 3000 or 6000 mg daily for 8 weeks had no effect on body weight.
  • Cancer : Preliminary research suggests that guggul extract may help fight tumors. One 2007 study on human cells found that guggulsterone (a compound found in guggul) induced the death of Prostate Cancer cells, while a 2008 report revealed that guggulsterone thwarted the growth of skin tumors in mice. Guggulsterone is confirmed to be a cancer stem cell killer. Cancer stem cells are largely responsible for the failure of conventional cancer treatment.

Used in Patent medicine