Indian Fumitory

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Fumaria indica

Other names : Pittapapada, Pid-papra, शहतरा, Shahtra, पापड़ा, Papara, पित्तपापड़ा, Pit papra, Parpat, Parpatakam, धुकुरे Dhukure, पर्पट Parpata, पर्पटकः Parpatakah, Chatarashi, Fumaria indica (Hausskn.), Pugsley Fumaria indica, Fumaria parviflora var. indica, Fumaria vaillantii var. indica.
See also : Common Fumitory

Special Precautions of Indian Fumitory

Benefits and uses of Indian Fumitory are

The plant is sold under the name pitpapra in Ayurvedic bazaars. It is also used in the Unani system of medicine and incorporated into trifala shahtara.

  • Indian Fumitory is used in aches and pains, diarrhoea, fever, influenza and liver complaints.
  • The herb mixed with honey mar be taken internally to prevent vomiting.
  • A cold infusion of the plant is used to treat wasting diseases of children and to help cooling during fever and in the treatment of constipation and dyspepsia.
  • It is used as a blood purifier for skin diseases and applied externally in leucoderma and as a fomentation for swollen joints.
  • The dried plant is also used as an anthelmintic, diuretic and diaphoretic and, in combination with black pepper, for jaundice.
  • Hepatoprotective activity
  • Antiviral activity : Study reported that two phytochemicals from Fumaria indica, i.e. Narlumicine and Oxysanguinarine act as dengue virus (DENV) inhibitors. They exhibited binding affinity ≥ -8 kcal/mol against DENV4-NS4B. Furthermore, DFT based analysis revealed high reactivity for these phytochemicals in the binding pocket of DENV4-NS4B, based on ELUMO, EHOMO and band energy gap.
  • Gastroprotective activity : Study revealed that both Methanolic extract of Fumarica indica shows potent gastro-protective agents against chronic unavoidable stress-induced ulcers and strongly suggest that they act as regulators or modulators of monoamine, corticosterone and cytokine homeostasis.
  • Ant-inflammatory and Analgesic activity : Study showed significant anti-inflammatory activities of Fumaria indica in carrageenan-induced edema and cotton pallet granuloma even after their lowest tested doses. Significant analgesic activities was also observed in hot plate and tale flick tests
  • Antihypertensive activity : Broad survey has revealed that Fumaria indica is one of the various herbs people have been using against hypertension with very satisfactory results.
  • Cognitive Modulating Activity : Fumaria indica showed dose-dependent decrease in brain AChE activity and increase in muscarinic receptor density, and such was also the case for its observed beneficial effects on the brain antioxidative status. Fumaria indica also inhibited the scopolamine-induced overexpression of the three tested cytokines observed in rat's brain. It also possesses nootropic-like beneficial effects on cognitive functions.
  • Antianxiety activity : Study strongly suggest that Fumaria indica is a functionally novel type of antianxiety agent, and that inhibition of cytokine expressions in the brain could be involved in its mode of action.
  • Chemoprotective activity : Experimental observations powerfully supports that F. indica exerts chemopreventive effect by suppressing the tumor burden and restoring the activities of hepatic cancer marker enzymes on NDEA and CCl4-induced hepatocarcinogenesis in Wistar rats.
  • Anti-inflammatory and anti-nociceptive activity : Oral administration of F. indica dry extract (100, 200 and 400 mg kg-1) exhibited dose dependent and significant anti-inflammatory activity in acute (carrageenean and histamine induced hind paw oedema, p <0.05) and chronic cotton pellet granuloma models of inflammation, p< 0.01). A significant anti-nociceptive activity was evidenced in mice;6.6 67.7% (p < 0.01) protection in mechanical, 33.9-125.1% (p <0.05) protection in thermal induced pain and 22.2-73.9% (p < 0.05) protection in acetic acid-induced writhing.
  • Antifungal activity : The alkaloid fuyuziphine isolated from the whole plantof Fumaria indica showed inhibitive effect against spore germination of some plant pathogenic fungi (Collectotrichum sp., C. gloeosporioides, C. falcatum, Curvularia maculans, C. lunata, Erysiphe cichoracearum, Helminthosporium pennisetti, Oidium erysiphoides, Ustilago cynodontis, Alternaria chieranthi, A. melongenae, A. brassicicola and A. solani). Curvularia lunata, Oidium erysiphoides, Alternaria brassicicola and A. solani did not germinate at 750 and 1000 ppm and Colletotrichum gloeosporioides, C. falcatum, Curvularia maculans were inhibited at 1000 ppm for 24 hr incubation. Germination of most fungi was significantly inhibited at 100~750 ppm.
  • Antihelminthic activity : Ethanolic extracts of the whole plant of Fumaria parviflora (Papaveraceae) showed an anthelmintic efficacy of up to 93%, relative to pyrantel tartrate. Ethanol extract of F. parviflora caused a strong reduction of the faecal egg counts (100%) and a 78.2 and 88.8% reduction of adult H.contortus and T. colubriformis on day 13 post-treatment. The extract was as effective as the reference compound pyrantel tartrate.
  • Spasmogenic and spasmolytic activity : The crude extract of Fumaria indica whole plant (Fi.Cr) and its fractions showed spasmogenic and spasmolytic. Data indicate that the presence of cholinergic and CCB constituents in Fumaria indica may explain the respective traditional use of Fumaria indica in constipation and diarrhea .

References

The Journal of Phytopharmacology 2017; 6(6): 352-355 / Pharmacological activity of Fumaria indica - A review - Dr. Gowher Guna