See also :* [[Essential Fatty Acids]]*[[Omega-6 fatty acids]]* [[Linoleic Acid]]* [[Borage Seed Oil]]* [[Evening Primrose]]Gamma-linolenic acid (GLA) is an omega-formed out of Parent Omega 6 fatty [[Linoleic Acid]]. Your body converts this into Gamma-linolenic acid that GLA and other compounds. It is found mostly in plant based oils such as borrage seed oil, evening primrose oil, and black currant seed oil. Omega-6 fatty acids are considered essential fatty acids: They are necessary for human health, but the body can' t make them -- you have to get them through food. Along with omega-3 fatty acids, omega-6 fatty acids play a crucial role in brain function, as well as normal growth and development. Also known as polyunsaturated fatty acids (PUFAs), they help stimulate skin and hair growth, maintain bone health, regulate metabolism, and maintain the reproductive system.
There are several different types of omega-6 fatty acids. Most omega-6 fatty acids in the diet come from vegetable oils in the form of linoleic acid (LA). The body converts linoleic acid to GLA and then to arachidonic acid (AA). GLA can be gotten from several plant based oils including evening primrose oil, borage oil, and black currant seed oil. Most of these oils also contain some linoleic acid.
Many experts find the science supporting the use of omega-3 fatty acids to reduce inflammation and prevent diseases to be much stronger than that supporting GLA.
==Special Precautions of Gamma-linolenic acid==
Because of the potential for side effects and interactions with medications, dietary supplements should be taken only under the supervision of a knowledgeable health care provider.
*Do not take omega-6 fatty acids if you have a seizure disorder. Several reports describe seizures in people taking evening primrose oil. Some of these seizures developed in people with a previous seizure disorder, or in people taking evening primrose oil in combination with anesthetics. People who plan to have surgery requiring anesthesia should stop taking evening primrose oil 2 weeks ahead of time.
*Pregnant women should not take borage seed oil, and possibly other sources of GLA, because they may harm the fetus and induce early labor. Talk with your physician.
*Avoid doses of GLA greater than 3,000 mg per day. High levels may increase inflammation in the body.
*Side effects of evening primrose oil can include occasional headache, abdominal pain, nausea, and loose stools. In animal studies, GLA is reported to decrease blood pressure. Early results in human studies do not show consistent changes in blood pressure.
*Laboratory studies suggest that omega-6 fatty acids, such as the fat found in corn oil, promote the growth of prostate tumor cells. Until more research is done, health care professionals recommend not taking omega-6 fatty acids, including GLA, if you are at risk for or have prostate cancer.<br>
Possible Interactions:
*If you are currently being treated with any of the following medications, you shouldnot use omega-6 supplements without first talking to your health care provider.
*Blood thinning medications -- People taking blood thinning medications should not take omega-6 fatty acid supplements without consulting a health care provider. Omega-6 and omega-3 fatty acids may increase the risk of bleeding. These medications include: Warfarin (Coumadin), Clopidogrel (Plavix), Aspirin, Ceftazidime -- Gamma linolenic acid (GLA) may increase the effectiveness of ceftazidime. Ceftazidinme, an antibiotic in a class known as cephalosporins, is used to treat a variety of bacterial infections.
*Chemotherapy for cancer -- GLA may increase the effects of anti cancer treatments, such as doxorubicin, cisplatin, carboplatin, idarubicin, mitoxantrone, tamoxifen, vincristine, and vinblastine.
*Cyclosporine -- Cyclosporine is a medication used to suppress the immune system after organ transplant. Taking omega-6 fatty acids with cyclosporine may increase the immunosuppressive effects of this medication. It may also protect against kidney damage (a potential side effect from this medication).
*Phenothiazines -- People taking a class of medications called phenothiazines to treat schizophrenia should not take evening primrose oil. Evening primrose oil may interact with these medications and increase the risk of seizures. The same may be true for other omega-6 supplements. These medications include: Chlorpromazine (Thorazine), Fluphenazine (Stelazine), Perphenazine (Trilafon), Promethazine (Compazine), Thioridazine (Mellaril)
==The benefits of Gamma-linolenic acid are==
* Diabetic neuropathy : Some studies show that taking gamma linolenic acid (GLA) for 6 months or more may reduce symptoms of nerve pain in people with diabetic neuropathy. People who have good blood sugar control may find GLA more effective than those with poor blood sugar control.
* [[Diabetes]] : GLA is a fatty acid that the body converts to a hormone-like substance called prostaglandin E1 (PGE1),” says the University of Michigan Health System (UMHS). Men and women with Type 1 and Type 2 diabetes may have a metabolic problem that prevents the body from making GLA, explains the UMHS.
*Rheumatoid arthritis : Studies are mixed as to whether evening primrose oil helps reduce symptoms of rheumatoid arthritis. Some preliminary evidence suggests evening primrose oil may reduce pain, swelling, and morning stiffness, but other studies have found no effect. When using GLA for arthritis symptoms, it may take 1 - 3 months to see any benefit. It is unlikely that evening primrose oil would help stop progression of the disease, so joint damage could still occur.
*Allergies : GLA from evening primrose oil or other sources has a longstanding history of folk use for allergies. And women and children who are prone to allergies appear to have lower levels of GLA in breast milk and blood. However, there is no good scientific evidence that taking GLA helps reduce allergy symptoms. Well conducted research studies are needed.Before you decide to try GLA for allergies, speak with your health care provider to determine if it is safe for you. Then track your allergy symptoms closely for any signs of improvement or lack of improvement.
*Osteoporosis : Some studies suggest that people who don' t get enough of some essential fatty acids (particularly EPA and GLA) are more likely to have bone loss than those with normal levels of these fatty acids. In a study of women over 65 with osteoporosis, those who took EPA and GLA supplements had less bone loss over 3 years than those who took placebo. Many of these women also experienced an increase in bone density.
*Premenstrual syndrome (PMS) : Although most studies have found no effect, some women report relief of PMS symptoms when using GLA. The symptoms that seem to be helped the most are breast tenderness and feelings of depression, as well as irritability and swelling and bloating from fluid retention.
== Dietary Sources ==
GLA is found in the plant seed oils of evening primrose, black currant, borage, and fungal oils. Spirulina (often called blue green algae) also contains GLA.
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