Difference between revisions of "Phellinus Linteus"

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(Created page with "==Special Precautions of Phellinus Linteus== ==The benefits of Phellinus Linteus are== Phellinus linteus, also known as mesima or black hoof fungus, is a species of mushroom that...")
 
(→‎The benefits of Phellinus Linteus are)
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==Special Precautions of Phellinus Linteus==
 
==Special Precautions of Phellinus Linteus==
 
==The benefits of Phellinus Linteus are==
 
==The benefits of Phellinus Linteus are==
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Phellinus linteus, also known as mesima or black hoof fungus, is a species of mushroom that has traditionally been used as an anti-cancer drug. Preliminary medical studies suggest that this mushroom can effectively kill cancerous cells without damaging other cells in an organism. Though more studies are needed to determine its effectiveness, initial results are promising. This mushroom is also traditionally used to treat gastrointestinal problems.
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It is known that polysaccharides extracted from the Phellinus linteus mushroom  
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*Recent medical studies have shown that Phellinus linteus may be effective at treating cancer. It has the potential to suppress tumor growth and may keep cancer from metastasizing, or spreading to other parts of the body. The chemicals in this mushroom are toxic to cancerous cells but do not harm normal cells. They are believed to be effective against cancers of the lung, breast, prostate, and skin and can be safely used to supplement or enhance the effectiveness of traditional cancer treatments.Anecdotal evidence suggests that Phellinus linteus may be responsible for the sudden and spontaneous regression of a number of types of cancer. Patients diagnosed with lung and skin cancer have occasionally shown complete recovery, possibly due to the use of Phellinus linteus. Though complete recovery is extremely rare, treatment with Phellinus linteus does not seem to have any adverse effects, so taking this medication along with other cancer treatments is not likely to cause harm to a patient.
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possess anti-tumor activity. Phellinus linteus mushroom indirectly augments the
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*Treatment with Phellinus linteus can be given as an immune booster as well. It has been shown to greatly increase the activity of white blood cells, which can help fight illness and infection. This mushroom is also known to be an antioxidant, a substance that increases immune function.
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host's immune system against cancer cells and reduced tumor proliferation.
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*Mouth and stomach ulcers can be treated withPhellinus linteus. It can reduce swelling and increase immune function in these illnesses, helping the body's own immune system to effectively combat the disorders. The anti-inflammatory properties of the mushroom can reduce swelling in other parts of the body as well.
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*Prostate Cancer Cells : Researchers from Harvard Medical School demonstrated that LNCaP cells expressing the androgen receptor are highly susceptible to apoptosis in response to treatment with high doses of Phellinus linteus. They also found that caspase 2 is a key target in the determination of the susceptibility of prostate cancer cells to PL-induced apoptosis.
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The medical properties of Phellinus linteus have been known to doctors from Korea, Japan, China, and neighboring countries for centuries. Though this mushroom has been used medicinally for a long time, it was only in the 1990s and 2000s that testing was begun to determine its effectiveness and its mechanism of action in the treatment of various disorders. As of 2011, it has not been accepted as an official treatment for any condition, though medical professionals are hopeful that further studies will confirm its cancer fighting properties.
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*Lung Cancer Cells : Researchers from Boston University School of Medicine reported that high doses of Phellinus linteus mushroom could make lung cancer cells to undergo apoptosis in a dose-dependent fashion while low doses of Phellinus linteus mushroom allows the arrest of the cell-cycle. Furthermore, the low dose of Phellinus linteus mushroom was able to synergize with doxorubicin to induce apoptosis in the lung cancer cells.
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*A study of rats in Korea showed that pretreatment with mycelial culture of Phellinus linteus provided protection of the gastric mucosa from ethanol-induced injury by maintaining the mucus barrier. The ulcer was induced by ethanol. Pretreatment with mycelial culture of Phellinus linteus at doses of 20 and 60 mg/kg, led to a significant decrease of bleeding and ulcer index.
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*Melanoma Cells : Korean researchers showed that Phellinus linteus significantly inhibited melanoma cell metastasis in mice. In the study, Phellinus linteus directly inhibited cancer cell adhesion to and invasion through the extracellular matrix.
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*Colon Cancer Cells : Phellinus linteus inhibited the proliferation and colony formation of SW480 human colon cancer cells. Flow cytometry analysis showed that Phellinus linteus increased the populations of both apoptotic sub-G1 and G2/M phase.
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*Neuroblastoma : Researchers from Korea found that the anti-proliferative and apoptotic effects of mycelium extracts of Phellinus linteus on neuroblastoma were associated with a significant induction of the Bax and cyclin-dependent kinase inhibitor p21.
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*Anti-inflammatory activities. Phellinus linteus showd an anti-inflammatory activity via mediation of HO-1 in an in vitro inflammation model.
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*Anti-bacterial activities. Methanol extract and its fractions (CHCl3, n-BuOH and H2O) of the fruit body of Phellinus linteus mushroom showed antibacterial activity against methicillin-resistant Staphylococcus aureus.
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*Antioxidant activities : Hispidin, antioxidant extracted from the mycelial culture broth of Phellinus linteus, inhibited 22.6 and 56.8% of the super oxide anion radical, 79.4 and 95.3% of the hydroxyl radical, and 28.1 and 85.5% of the DPPH radical at 0.1 and 1.0 mM,respectively.
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*Liver Protection : In a study, an ethyl acetate fraction of mycelial culture of Phellinus linteus protected hepatocytes from H(2)O(2)- or galactosamine-induced injury.
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COMMENTS
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Phellinus linteus may have lots of health benefits, but there are limited clinical studies.
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Results of animal models and cell culture may not be same in human body. In
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addition, studies on its side effects are needed.
 
[[Category:Treatments]]
 
[[Category:Treatments]]
 
[[Category:Medicinal mushrooms]]
 
[[Category:Medicinal mushrooms]]

Revision as of 13:11, 4 March 2012

Special Precautions of Phellinus Linteus

The benefits of Phellinus Linteus are

It is known that polysaccharides extracted from the Phellinus linteus mushroom possess anti-tumor activity. Phellinus linteus mushroom indirectly augments the host's immune system against cancer cells and reduced tumor proliferation.

  • Prostate Cancer Cells : Researchers from Harvard Medical School demonstrated that LNCaP cells expressing the androgen receptor are highly susceptible to apoptosis in response to treatment with high doses of Phellinus linteus. They also found that caspase 2 is a key target in the determination of the susceptibility of prostate cancer cells to PL-induced apoptosis.
  • Lung Cancer Cells : Researchers from Boston University School of Medicine reported that high doses of Phellinus linteus mushroom could make lung cancer cells to undergo apoptosis in a dose-dependent fashion while low doses of Phellinus linteus mushroom allows the arrest of the cell-cycle. Furthermore, the low dose of Phellinus linteus mushroom was able to synergize with doxorubicin to induce apoptosis in the lung cancer cells.
  • A study of rats in Korea showed that pretreatment with mycelial culture of Phellinus linteus provided protection of the gastric mucosa from ethanol-induced injury by maintaining the mucus barrier. The ulcer was induced by ethanol. Pretreatment with mycelial culture of Phellinus linteus at doses of 20 and 60 mg/kg, led to a significant decrease of bleeding and ulcer index.
  • Melanoma Cells : Korean researchers showed that Phellinus linteus significantly inhibited melanoma cell metastasis in mice. In the study, Phellinus linteus directly inhibited cancer cell adhesion to and invasion through the extracellular matrix.
  • Colon Cancer Cells : Phellinus linteus inhibited the proliferation and colony formation of SW480 human colon cancer cells. Flow cytometry analysis showed that Phellinus linteus increased the populations of both apoptotic sub-G1 and G2/M phase.
  • Neuroblastoma : Researchers from Korea found that the anti-proliferative and apoptotic effects of mycelium extracts of Phellinus linteus on neuroblastoma were associated with a significant induction of the Bax and cyclin-dependent kinase inhibitor p21.
  • Anti-inflammatory activities. Phellinus linteus showd an anti-inflammatory activity via mediation of HO-1 in an in vitro inflammation model.
  • Anti-bacterial activities. Methanol extract and its fractions (CHCl3, n-BuOH and H2O) of the fruit body of Phellinus linteus mushroom showed antibacterial activity against methicillin-resistant Staphylococcus aureus.
  • Antioxidant activities : Hispidin, antioxidant extracted from the mycelial culture broth of Phellinus linteus, inhibited 22.6 and 56.8% of the super oxide anion radical, 79.4 and 95.3% of the hydroxyl radical, and 28.1 and 85.5% of the DPPH radical at 0.1 and 1.0 mM,respectively.
  • Liver Protection : In a study, an ethyl acetate fraction of mycelial culture of Phellinus linteus protected hepatocytes from H(2)O(2)- or galactosamine-induced injury.

COMMENTS Phellinus linteus may have lots of health benefits, but there are limited clinical studies. Results of animal models and cell culture may not be same in human body. In addition, studies on its side effects are needed.

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