Stephania Tetrandra

Other Names : Han Fang ji (Chinese: 漢防己; pinyin: hàn fáng jǐ)

Special Precautions of Stephania Tetrandra

• Guang fang ji preparations can contain toxic amounts of aristolochic acid when Aristolchia fanghi is substituted for Stephania tetrandra. Ingestion can lead to renal failure and even death; Aristolochia is used in TCM only with great caution. In May, 2000, the FDA began detaining any plants or medicines suspected of containing aristolochic acid, unless laboratory testing indicated they were negative for aristolochic acid. (Only tests which use a liquid chromatography/tandem mass spectrometry [LC/MS/MS] method with a precision better than 0.5 parts per million (PPM) are acceptable.)[4] The traditional route of ingestion of guang fang ji is via water decoction. Since aristolochic acid has low water solubility, water decoction is believed to be a much safer route than taking guang fang ji as an uncooked powder.
• Guang fang ji preparations can contain toxic amounts of aristolochic acid when Aristolchia fanghi is substituted for Stephania tetrandra. Ingestion can lead to renal failure and even death; Aristolochia is used in TCM only with great caution. In May, 2000, the FDA began detaining any plants or medicines suspected of containing aristolochic acid, unless laboratory testing indicated they were negative for aristolochic acid. (Only tests which use a liquid chromatography/tandem mass spectrometry [LC/MS/MS] method with a precision better than 0.5 parts per million (PPM) are acceptable.)The traditional route of ingestion of guang fang ji is via water decoction. Since aristolochic acid has low water solubility, water decoction is believed to be a much safer route than taking guang fang ji as an uncooked powder.

Benefits and uses of Stephania Tetrandra are

Fen fang ji is of low toxicity (standard dose is: 4.5 to 9 g, overdose can occur at 30-100 g) and is traditionally used to dispel wind and dampness to relieve pain and to promote diuresis.[citation needed] It is classified as acrid, bitter and cold. The part used is the root. Stephania contains tetrandrine, a potent smooth muscle relaxant under preliminary in vitro studies related to cardiovascular effects and some forms of cancer.