DIM

Special Precautions of DIM

DIM may be helpful in minimizing possible cancer risks of hormone replacement (both estrogen and testosterone based) by affecting the actions of these hormones on the breast and prostate, as well as confer anti-tumor effects on the thyroid, lung and colon. On the other hand, it should be noted that excessively high doses seem to be associated with toxicity and pro-tumor effects in animal research(12). However, when the equivalent of a human dose of ~600mg / day (for a 220lb bodybuilder; 2-3 times the typically suggested dose), was given to rats for 32 days, neither body weight, blood chemistry nor histology of liver, kidney or bone were affected, suggesting minimal adverse consequences, at least for rodents, at this dose.In one study of healthy adults, increasing the dose of DIM from 200mg to 300mg did not further elevate DIM blood levels. Additionally, side effects below 300mg/day were not found to be dose-dependent. As reviewed by Reed et al., compared to an equivalent dose of I3C, oral supplementation with DIM produces 2-3 times higher DIM, and is well tolerated in the 200-400mg/ day range, when split over two doses.

The benefits of DIM are

• Hormonal acne
• Preventing negative effects of testosterone supplementation
• Estrogen dominance
• Weight loss
• Potential cancer therapy
• Thyroid disorders
• Menopause