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*Although little is known about the safety of long-term use of acerola extract, there is some concern that oral intake of acerola may cause certain side effects (including nausea, diarrhea, headache, redness of skin and kidney stones).*Some people have reported adverse reactions to eating acerola cherries, including upset stomachs, sleeplessness, and insomnia. Too many acerola cherries can also cause diarrhea. The high levels of vitamin C can also be dangerous if you suffer from gout, as it can boost levels of uric acid. Other than that, acerola cherries are not commonly known as an allergenic food.

The fruit is edible and widely consumed in the species' native area, and is cultivated elsewhere for its high vitamin C content. To date, very few scientific studies have tested the potential health benefits of acerola. Although there is no evidence from clinical trials to show that acerola can enhance health, some preliminary findings from laboratory research and animal-based studies indicate that acerola may have some beneficial effects.