Bauhinia Variegata

Other names : Orchid tree, Camel's Foot Tree, Mountain-ebony, Kachanar, kanchana, Koral, Devakanchanamu, Mandare, Chapmakati, Koral, kanchan, Kanchanara, Gandari, Kancanara

Benefits and uses of Bauhinia Variegata are

• Antibacterial: Evaluation of antibacterial activity and phytochemical analysis of Bauhinia variegata L. bark: Defatted acetone and methanol extracts showed the most antibacterial activity. (1)
• Antibacterial: The aqueous and methanol extracts of 12 plants from different families was studied for antibacterial activity against B cereus, S epidermis, E aerogenes, P vulgari and S typhimurium. Among the plant screened, B variegata bark showed the best antibacterial activity. (12)
• Antiinflammatory: Study isolated six flavonoids and one triterpene caffeate. The seven compound significantly and dose-dependently inhibited function involved in the inflammatory proceses. Results support the folkloric use of BV in its use for inflammatory conditions.
• Antiinflammatory / Flavonol Glycoside: Study yielded a novel flavonol glycoside 5,7,3',4'-tetrahydroxy-3-methoxy-7-O-alpha-L-rhamnopyranosyl(1-->3)-)-beta-galactopyranoside from the root which showed anti-inflammatory activity. (6)
• Hepatoprotective: Hepatoprotective Properties of Bauhinia variegata Bark Extract: In carbon tetrachloride intoxicated rats, extract of stem bark of Bv showed significant hepatoprotective actisvity and a promising agent for that purpose. (7)
• Chemopreventive / Cytotoxic: Chemoprevention and cytotoxic effect of Bauhinia variegata against N-nitrosodiethylamine (DEN) induced liver tumors and human cancer cell lines: Results showed chemopreventive and cytotoxic effect of ethanol extract of BV against induced DEN liver tumor and human cancer lines. (14)
• Antitumor / Cytotoxic: Ethanol extract of B variegata evaluated against Dalton's ascitic lymphoma in Swiss albino mice showed significant enhancement of survival time and reverse hematologic parameters consequent to tumor inoculation. (5)
• Antioxidant / Antihyperlipidemic: Study of alcoholic and aqueou extract of Bv effectively decreased plasma cholesterol, triglycerides, LDL, VLDL and increase HDL levels and also showed significant antioxidant activity. EBV was found to be a potent cytotoxic toward EAC tumor cell. (9)
• Pharmacognosy / Phytochemicals: Study yielded steroid, saponin, flavonoids, alkaloids and tannins.
• Immunomodulatory: Study on the ethanolic extract of the stem bark of Bv showed significant increase in the primary and secondary humoral antibody response and show promise as an immunomodulatory agent, probably through stimulation of both the specific and nonspecific arms of immunity.
• Immunomodulatory: Study evaluating the immunomodulatory activity of stem bark extracts showed predominantly significant activity on in vitro human neutrophils in all parameters. Results suggested a possible immunostimulating effect. (10)
• Anti-Diabetic: Study showed the presence of insulin-like properties in the leave of Bv. The activity of this insulin-like protein on serum glucoe levels in diabetic mice was similar to that of commercial swine insulin used a control. (11)
• Antihelmintic: Study showed significant anthelmintic activity by methanolic extract of B variegata against both mature male and female Haemonchu contortus. (13)
• Hypolipidemic: Study of extracts of bark of Bauhinia variegata showed significant reduction in total cholesterol and LDL in Triton-induced hyperlipidemia in rats. The HDL increase was not significant.
• Anti-Obesity Effect: Study of root extract showed an anti-obesity activity attributed to its hypophagic, hypoglycemic and hypolipidemic effect. (16)
• Nephroprotective / Antioxidant: Study of ethanol and aqueous roots extracts in gentamicin-induced nephrotoxicity in rats showed significant nephroprotective activity. Antioxidant activity was shown on a DPPH assay model. (17)
• Chemopreventive: Study of B. variegata bark in mice showed a chemopreventive potential against DMBA-induced skin carcinogenesis. (18)
• Antimutagenic: Study of bark extract B. variegata showed a preventive potential against cyclophosphamide-induced micronucleus formation in Swiss mouse bone marrow cells.
• Antipyretic: Study of ethanolic extract showed antipyretic activity probably through inhibitionof prostaglandin synthesis in the hypothalamus. (19)
• Anti-Eosinophilic: Study of aqueous and ethanl extracts of BV against milk-induced leucocytosis and eosinophic in mice showed a significant dose-dependent reduction in total leucocyte and eosinophil counts suggesting an antieosinophilic activity. (20)
• Anti-Ulcer / Analgesic: Study of root extracts showed significant dose-dependent analgesic and significant anti-ulcer activity. The activities were attributed to the presence of flavonoids. (21)
• Chemopreventive / Cytotoxic: Study of ethanol extract of BV showed significant chemopreventive and cytotoxic effect against DEN (N-nitrosodiethylamine)-induced liver tumor and human cancer cell lines. (22)
• Antioxidant: Study showed the extract of leaves of G. pentaphylla and Bauhinia variegata inhibited free radical scavenging activity. The effect was attributed to flavonoids, phenolics and other phytochemical constituents. (24)
• Antipyretic: Study of ethanolic extracts of B. variegata and Glcosmis pentaphylla exhibited significant antipyretic activities in Brewer's yeast induced pyrexia in rats. Activity was attributed to inhhibition of prostaglandin synthesis in the hypothalamus. (25)
• Chemopreventive / DBMA-induced Skin Carcinogenesis: Study investigated the anticarcinogenic activity of B. variegata bark extract in a skin papilloma model in Swiss albino mice. Results showed a chemopreventive role for bark extracts against DBMA-induced skin carcinogenesis in mice with decrease in rate of tumor incidence, number of papillomas, tumor yield and tumor burden. (26)
• Anti-Inflammatory: Study investigated the anti-inflammatory potential of leaves, barks, and roots using three in vivo animal models: carrageenan induced rat paw edema, cotton pellets induced granuloma formation, and adjuvant induced arthritis in rat. An ethanol extract and petroleum ether extract demonstrated anti-inflammatory activity in the three bioassays. (27)
• Analgesic / Antifungal / Cytotoxic: Study investigating an ethanolic extract of the plant showed analgesci activity by eddy's hot plate method, in vitro cytotoxicity against DLA cells lines by Typan blue assay method, and good antifungal activity against Aspergillus fumigatus and Candida albicans. (28)
• Radical Scavenging / Natural Antioxidant: Study of leaf, stem bark, floral buds extracts showed remarkable concentration dependent free radical scavenging and reducing power. Results suggest a potential source of natural antioxidant. (29)
• Antimicrobial / Anticancer Activities: Study evaluated extracts of B. variegata generated through in vivo and in vitro processes for antibacterial and anticancer activities. Activity was greater against gram positive bacteria compared to gram negative bacterial. In vitro cytotoxicity screening showed inhibition of EAC mouse cell lines. (30)

References

(1) Evaluation of antibacterial activity and phytochemical analysis of Bauhinia variegata L. bark
(2) Antinociceptive, Anti-Inflammatory and Antipyretic Properties of the Aqueous Extract of Bauhinia purpurea Leaves in Experimental Animals
(3) Antiinflammatory Activities of Flavonoids and a Triterpene Caffeate Isolated from Bauhinia variegata / Yerra Kotsewara Rao et al / Phytotherapy Research • Volume 22 Issue 7, Pages 957 - 962 / DOI 10.1002/ptr.2448<br> (4) Chemoprevention and cytotoxic effect of Bauhinia variegata against N-nitrosodiethylamine induced liver tumors and human cancer cell lines / B Rajkapoor et al / Journal of Ethnopharmacology Volume 104, Issue 3, 6 April 2006, Pages 407-409 / doi:10.1016/j.jep.2005.08.074
(5) Antitumour activity of Bauhinia variegata on Dalton’s ascitic lymphoma / B Rajkapoor et al / Journal of Ethnopharmacology • Volume 89, Issue 1, November 2003, Pages 107-109 / doi:10.1016/S0378-8741(03)00264-2
(6) Anti-inflammatory activity of a novel flavonol glycoside from the Bauhinia variegata Linn./ Yadava R N and Reddy V M / Nat Prod Res. 2003 Jun;17(3):165-9 /
(7) In vitro antioxidant and antihyperlipidemic activities of Bauhinia variegata Linn / G P Rajani and Purnima Ashok / Indian J Pharmacol • 2009 ;41:227-32
(8) Pharmacognostical and Phytochemical Screening of Bauhinia variegata Linn leaves / Rajeh Gupta et al / Journal of Pharmacy Research 2009, 2(7),1196-1198
(9) Hepatoprotective Properties of Bauhinia variegata Bark Extract / Surendra Bodakhe and Alpana Ram / YAKUGAKU ZASSHI • Vol. 127 (2007) , No. 9 1503-1507
(10) Evaluation of the immunomodulatory activity of ethanolic extract of the stem bark of Bauhinia variegata Linn / M M Ghaisas et al / Int J Green Pharm 2009;3:70-4
(11) Isolation and intracellular localization of insulin-like proteins from leaves of Bauhinia variegata / Azevedo C R et al / Brazilian journal of medical and biological research • 2006, vol. 39, no11, pp. 1435-1444/
(12) Antibacterial and phytochemical studies on twelve species of Indian medicinal plants / Jigna Parekh and Sumitra Chanda / African Journal of Biomedical Research • Vol 10: 175-181, 2007
(13) Anthelmintic activity of leaves of Bauhinia variegata / Anita Singh et al / Indian Veterinary Journal /
(14) Bauhinia variegata / Ayurvedic Medicinal Plants
(15) PROTECTIVE EFFECT OF BAUHINIA VARIEGATA EXTRACTS ON TRITON INDUCED HYPERLIPIDEMIA IN RATS / Biradar SS and Patil PA / Journal of Cell and Tissue Research Vol. 11(2) 2785-2788 (2011)
(16) EVALUATION OF ETHANOLIC EXTRACT OF BAUHINIA VARIEGATA LINN. IN HIGH FAT DIET INDUCED OBESITY IN RATS / *Yash Prashar, S. Venkataraman / International Journal of Phytopharmacology, 1(2), 2010, 103-108.
(17) Effect of Ethanolic and Aqueous Extracts of Bauhinia Variegata Linn. on Gentamicin-Induced Nephrotoxicity in Rats / Rajesh Kumar Sharma*, Rajani G.P., Vivek Sharma, Komala N / Ind J Pharm Edu Res, Apr-Jun, 2011/ Vol 45/ Issue 2
(18) Chemopreventive potential of Bauhinia variegata against DMBA-induced skin papillomagenesis in Swiss albino mice / Manju Singh and Raosaheb K. Kale / Cancer Prevention Research: January 2010; Volume 3, No 1, Suppl 1 / doi: 10.1158/1940-6207.PREV-09-A64
(19) A Comparative Antipyretic Activity of the Crude Extracts of the Ariel Parts of Glycosmis pentaphylla and Bauhinia variegata / Mandal S, Upadhyay N, Sharma I, Rohit S, Mandloi A / Recent Research in Science and Technology 2011, 3(7): 16-18
(20) Evaluation of effects of Bauhinia variegata stem bark extracts against milk-induced eosinophilia in mice / Ravindra G Mali, Avinash S Dhake / J Adv Pharm Tech Res, 2011;2:132-4 / DOI: 10.4103/2231-4040.82949
(21) Analgesic and Anti-Ulcer Activities of Ethanol and Aqueous Extracts of Roots of Bauhinia variegata Linn. / Yanni R Kumar and G P Rajani / Intern Journ of Pharmacology 7(5):616-622, 2011
(22) Chemoprevention and cytotoxic effect of Bauhinia variegata against N-nitrosodiethylamine induced liver tumors and human cancer cell line / B. Rajkapoor, B. Jayakar, N. Murugesh and D. Sakthisekaran / Journal of Ethnopharmacology, Volume 104, Issue 3, 6 April 2006, Pages 407-409 / doi:10.1016/j.jep.2005.08.074
(23) In-vitro Immunomodulatory Activity of extracts of Bauhinia vareigata Linn Stem Bark on Human Neutrophils / J K Patil, S S Jalalpure, S Hamid, R A Ahirrao / IJPT, July 2010, Vol 9, No 2, 41-46
(24) In-vitro Comparative Antioxidant Activity of Ethanolic Extracts of Glycosmis pentaphylla and Bauhinia variegata / Bhatia L, Bishnoi H, Chauhan P, Kinja K, Shailesh S / Recent Research in Science and Technology 2011, 3(7): 01-03
(25) A Comparative Antipyretic Activity of the Crude Extracts of the Ariel Parts of Glycosmis pentaphylla and Bauhinia variegata / Mandal S, Upadhyay N, Sharma I, Rohit S, Mandloi A / Recent Research in Science and Technology 2011, 3(7): 16-18
(26) Effect of Bauhinia Variegate Bark Extract on DMBA-Induced Mouse Skin Carcinogenesis: A Preliminary Study / Sonam Pandey and R.C. Agrawal / Global Journal of Pharmacology, 3 (3): 158-162, 2009 ISSN 1992-0075 © IDOSI Publications, 2009
(27) In Vivo Study for Anti-inflammatory Activity of Bauhinia variegata L. Leaves / Santanu Saha, Subrahmanyam, K.S. Chandrashekar and Shashidhara C. Shastry / Pharmaceutical Crops, 2011, 2, 70-73
(28) Analgesic, Antifungal and In-Vitro Cell Cytotoxic Studies of Bauhinia Variegata Bark Extract / Shyamkumar B*, Ishwar Bhat K / AJPTR, American Journal of PharmTech Research
(29) International Journal of Scientific and Research Publications, Volume 2, Issue 2, February 2012 1 ISSN 2250-3153
In-Vitro Antioxidant and Free Radical Scavenging Activity of Bauhinia Variegata Linn / Sonam Pandey*, R. C. Agrawal* and S. Maheshwar / International Journal of Scientific and Research Publications, Volume 2, Issue 2, February 2012