Calcium-D-Glucarate

Calcium D-glucarate is a substance made up of calcium and glucaric acid (a chemical compound found naturally in the human body and in a number of fruits and vegetables).

Special Precautions of Calcium-D-Glucarate

• Although little is known about the safety of long-term use of calcium D-glucarate, there's some concern that taking calcium D-glucarate in combination with certain medications may reduce the medications' effectiveness. These medications include atorvastatin (Lipitor), lorazepam (Ativan), and acetaminophen (Tylenol).
• Alcohol interacts with CALCIUM D-GLUCARATE
• Medications changed by the liver (Glucuronidated drugs) interacts with CALCIUM D-GLUCARATE
• Kanamycin interacts with CALCIUM D-GLUCARATE

The benefits of Calcium-D-Glucarate are

According to a 2003 report published in Integrative Cancer Therapies, consumption of fruits and vegetables naturally rich in glucaric acid "offers a promising cancer prevention approach." The report's authors note that glucaric acid may help protect against cancer by inhibiting beta-glucuronidase.

• Cancer : Calcium D-glucarate is often touted as a natural solution for the prevention of certain types of cancer. Because calcium D-glucarate is thought to decrease the body's levels of the hormone estrogen, proponents claim that taking calcium D-glucarate can help a number of fight hormone-dependent cancers (such as cancer of the breast, prostate, and colon). So far, most of the findings on the health effects of calcium D-glucarate come from laboratory research and animal-based studies. Although there is currently a lack of clinical trials testing the use of calcium D-glucarate in treatment of any health condition, preliminary research suggests that calcium D-glucarate shows promise as an anti-cancer agent.In a 2002 report published in Alternative Medicine Review, for instance, investigators analyzed the available research on calcium D-glucarate and found that it may inhibit beta-glucuronidase (an enzyme associated with increased risk for various hormone-dependent cancers when it occurs at elevated levels).In addition, a 2007 study published in Oncology Letters determined that calcium D-glucarate may help fight lung cancer. In tests on mice, researchers found that calcium D-glucarate helped inhibit the growth of cancerous tumors in the lungs by curbing inflammation and inducing apoptosis (a type of programmed cell death essential for stopping the proliferation of cancer cells).There's also some evidence that calcium D-glucarate may protect against skin cancer. For example, a 2007 study published in the Journal of Environmental Pathology, Toxicology, and Oncology found that treating mice with calcium D-glucarate helped suppress the development of skin cancer by inducing apoptosis.
• Lowering Estrogen : This natural substance can aid the removal of excess estrogen in its ability to inhibit beta-glucuronidase activity in the body. D-glucarate helps eliminate toxins or xenoestrogens by conjugation.
• Detox : Upon ingestion and exposure to the acidic environment of the stomach, Calcium D- Glucarate is metabolized in the form of D-glucaric acid which helps bind toxins. In a healthy system detoxification occurs when a chemical binds to a toxin allowing it to be eliminated. However sometimes a bad enzyme called beta-glucuronidase can rip off the glucuronide conjugate and cause the toxin to remain in the body. Calcium D-Glucarate helps this function by allowing the glucuronidation process to happen and the exessive estrogen reduced from the body.

Food Sources of Calcium and Glucaric Acid

You can increase your intake of both calcium and glucaric acid by including certain foods in your diet. For instance, foods rich in calcium include dark green leafy vegetables, dairy products, and calcium-fortified cereals and soy products. Meanwhile, glucaric acid is available in the following foods:

• Vegetables : Broccoli, cabbage, kale and other members of the cabbage family have very high glucaric acid content. The "Journal of Nutrition" notes that vegetables belonging to the gourd family, including squash, watermelon and pumpkins also contain high glucaric acid. Lettuce, tomatoes and peppers are some other vegetables containing glucaric acid.
• Fruits : Of the fruits, oranges, apples and grapefruits contain the highest levels of glucaric acid. Other fruits with high glucaric acid content are those belonging to the Rosaceae family, which include strawberries and raspberries among others. Apricots, cherries and citrus fruits also contain glucaric acid.
• Legumes : Legumes such as peas, beans, lentils, soy and peanuts also contain high amounts of glucaric acid. The glucaric acid in bean sprouts is about 350 mg/100 g compared to only 10 mg/100 g in lettuce and grapes, according to "Journal of Nutrition."
• Kombucha is also very high in Glucaric acid, which has been shown to prevent cancer