Hesperidin

Other Names: Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïde d’Agrume, Bioflavonoïdes d’Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïdes, Concentré de Bioflavonoïdes, Extrait de Bioflavonoïdes, Extrait de Bioflavonoïdes d’Agrumes, Flavonoid, Flavonoïde, Hesperidin Methyl Chalcone, Hesperidina, Hespéridine, Trimethylhesperidin-chalcon.
Hesperidin is a plant chemical that is classified as a “bioflavonoid.” Hesperidin is a natural substance found primarily in unripe citrus fruit. Also available in supplement form, hesperidin is classified as a "bioflavonoid" (a type of compound with antioxidant effects).

Special Precautions of Hesperidin

• Hesperidin is likely safe when used orally for less than a year. However, it may be unsafe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers). Therefore, it's important to consult your physician if you're considering using hesperidin in combination with other medications.
• Hesperidin may trigger a number of side effects, including abdominal pain, diarrhea, and nausea.
• Pregnancy and breast-feeding: Not enough is known about the use of hesperidin during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Benefits and uses of Hesperidin are

• Chronic Venous Insufficiency (CVI) : A condition in which the veins do not efficiently return blood from the legs to the heart, chronic venous insufficiency is linked to problems like varicose veins, ankle swelling, and nighttime leg cramping. Supplements containing a combination of hesperidin, extract of the herb butcher's broom, and ascorbic acid (a form of vitamin C) may help treat chronic venous insufficiency, according to a 2007 study published in International Angiology. The study involved 124 people with chronic venous insufficiency. Every day for eight weeks, all study members took two capsules of the hespiridin/butcher's broom/ascorbic acid formula. Starting in the second week of the study, participants showed significant improvements in their symptoms (including pain, cramps, and swelling). The study's authors suggest that the hespiridin/butcher's broom/ascorbic acid may help treat chronic venous insufficiency by producing beneficial effects in patients' blood vessels.
• Hemorrhoids : In a 1994 study from Angiology, a supplement containing a combination of hespiridin and diosmin (another antioxidant compound available in citrus fruits) was found to aid in the treatment of hemorrhoids. For the study, 100 patients suffering from a hemorrhoid attack were treated with either the hespiridin/diosmin combination or a placebo for seven days. Compared to the placebo group, members of the supplement group showed significantly greater improvement in symptoms.More recent research on the use of hespiridin in treatment of hemorrhoids is lacking.
• Osteoporosis : Hesperidin shows promise for the prevention for postmenopausal osteoporosis, a 2003 study from the Journal of Nutrition suggests. In tests on mice, researchers discovered that a hesperidin-rich diet helped inhibit bone loss in animals whose ovaries had been removed.
• Treating leg ulcers caused by poor circulation, when used in combination with diosmin. Hesperidin, in combination with diosmin and a compression dressing, seems to improve healing of small ulcers (less than 10 cm) caused by poor blood circulation.
• Reducing arm swelling in lymphedema following surgery for breast cancer.
• High Cholesterol : Preliminary research indicates that a combination of hesperidin and vitamin E may help keep cholesterol in check. In a 2001 study on rats (published in the International Journal for Vitamin and Nutrition Research), scientists found that supplementing the animals' high-cholesterol diets with hesperidin and vitamin E helped reduce cholesterol levels in their blood.
• Cancer : Hesperidin may offer anti-cancer benefits, according to a preliminary study published in Phytotherapy Research in 2010. In tests on human breast cancer and prostate cancer cells, the study's authors found that hesperidin inhibited the spread and growth of cancer cells.