*Do not use if you have hypertension, hypokalemia edema, cirrhosis of the liver, cholestatic liver disorder, and diabetes.
* Long-term use of licorice can lead to fluid retention, increased blood pressure, loss of potassium and lowered libido as it contains [[isoflavones]] ([[phytoestrogens]]). It might lower the amount of serum testosterone slightly.
* Although the glycyrrhizin (glycyrrhizic acid) in Licorice fights the effects of [[hepatitis]], you should avoid [[Licorice]] root if you have chronic [[hepatitis]], cirrhosis of the liver, or any disease that impedes the flow of bile from the liver.
* licorice may reduce levels of the hormone testosterone in men. After one week of treatment with licorice, testosterone levels decreased 26%.
* Pregnant women should not use licorice at medicinal doses. There is a danger of high blood pressure or of a hormone imbalance that would harm the fetus.