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Although allergic reaction from supplementation is possible, there is no known toxicity associated with high doses of the phylloquinone (vitamin K1) or menaquinone (vitamin K2) forms of vitamin K and therefore no tolerable upper intake level (UL) has been set.Blood clotting (coagulation) studies in humans using 45 mg per day of vitamin K2 (as MK4)[25] and even up to 135 mg/day (45 mg three times daily) of K2 (as MK4),[50] showed no increase in blood clot risk. Even doses in rats as high as 250 mg/kg body weight did not alter the tendency for blood-clot formation to occur.However, * a synthetic SYNTHETIC form of vitamin K, vitamin K3 (menadione), is demonstrably toxic. In fact, the FDA has banned this synthetic form of the vitamin from over-the-counter supplements because large doses have been shown to cause allergic reactions, hemolytic anemia, and cytotoxicity in liver cells, formation of radicals from enzymes of leukocytes, weakens the immune system, mutagenic effects, damage to the natural vitamin K cycle, hemolytic anemia and hyperbilirubinemia, disturbing levels of calcium ions, vomiting, albuminuria, irritation of skin and mucous membranes, allergic reactions, eczema and unlike natural vitamin K - it builds up in tissue.[edit]* Drug interactions Interactions : Phylloquinone (K1)or menaquinone (K2) are capable of blocking the blood thinning action of anticoagulants like warfarin, which work by interfering with the action of vitamin K. They also reverse the tendency of these drugs to cause arterial calcification in the long term.* Vitamin K2 is considered safe for most people. However, taking high amounts of any form of vitamin K may be harmful to pregnant and breastfeeding women, patients receiving dialysis treatments due to kidney disease, and people with clotting problems caused by severe liver disease. In addition, vitamin K may interact with certain supplements (including coenzyme Q10 and vitamin E).

*Vitamin K1—phylloquinone, also known as phytonadione : Vitamin K1 makes up 90% of the vitamin K found in the Western diet. According to the National Institutes of Health, vitamin K1 is faster-acting, stronger, and more effective for some conditions than other forms of vitamin K. Consuming leafy green vegetables will provide an ample amount of this life-giving mineral and ensure optimal health.**Vitamin K1 is a necessary and important contributor to bone growth and overall bone health. **Vitamin K1 is best known in its ability to promote blood clotting. In fact, the letter “K” comes from the German term, koagulation. **Vitamin K1 is also an integral mineral for reducing prostate cancer risk. Regarding prostate cancer, it can reduce blood clotting, increase circulation, and in effect, support the healthy flow of urine and blood to the prostate. **Having high levels of Vitamin K1 may also reduce one’s risk for Alzheimer’s disease, reduce bruising, strengthen bones, improve skin, and reduce risk of developing heart disease (because it prevents hardening of the arteries).* vitamin K2, also known as menaquinone, is very different. Vitamin K2 is essential for your cardiovascular health because of its amazing ability to utilize calcium : Calcium belongs in our bones, not in our blood. When our vitamin K2 levels are low, calcium collects in our blood and can lead to calcification in our arteries. Vitamin K is associated with a significantly lower risk of coronary heart disease and atherosclerosis. There's also some evidence that K2 may boost bone health and reduce risk of osteoporosis. (See also : [[Vitamin D]]) Preliminary research indicates that vitamin K2 may aid in the treatment of some forms of cancer. For example, in a 2003 test-tube study from the International Journal of Oncology, researchers found that vitamin K2 may help promote the death of lung cancer cells.

*Vitamin K has more functions other than clotting; vitamin K is also beneficial in protecting the bones from fractures and in helping women in their menopausal stage from having unhealthy bones. The link between bone health and vitamin K has been researched extensively. Primary to this is the ability of vitamin K, in its menaquinone form, to impede the formation of osteoclasts. Osteoclasts are responsible for removing the minerals in the bone for proper body functioning. While these minerals are important in the body, we do not want too much of the osteoclastic activity as it can result to bone demineralization. Therefore, if vitamin K is increased, there will be less demineralization of bones, less chances of getting fractures.* vitamin K intake helps prevent diabetes.