[[File:Kokam.jpg|thumb|350px|left|CGarcinia indica]]
Other Names : Garcinia indica, Bindin, Biran, Bhirand, Bhinda, Katambi, Panarpuli, Ratamba or Amsool. In English language, it is also known by various names such as Mangosteen, wild Mangosteen, or Red Mango.The plant grows extensively on the western coast of India.
==Health Benefits and Uses of Kokam==
* Anticancer activity : The effects of garcinol and its oxidative derivatives have been investigated on the growth of HT-29 and HCT-116 colon cancer cells, as well as IEC-6 and INT-407 which are the normal immortalized intestinal cells [33]. Garcinol and its derivatives showed potent growth-inhibitory effects on all intestinal cells, with IC50 values in the range of 3.2-21.4 μM after 72 hr treatment. Garcinol was found to be more effective in inhibiting growth of cancer cells than that of normal immortalized cells.
* Anti-HIV Activity
* Anti-ulcer activity : Garcinol has potent free radical scavenging activity as judged from its interactions in three types of free radical generating systems. Its scavenging activity against hydroxyl radical has been found to be stronger than that of α-Tocopherol [17] while its other scavenging activities were found to be slightly weaker. Since hydroxyl radical is regarded as the most damaging Reactive Oxygen Species (ROS), garcinol is expected to be useful for preventing diseases caused by the hydroxyl radical damages such as stress-induced gastric ulcer. research has shown that this compound could become a viable alternative to the antibiotics used in the treatment of Helicobacter pylori infection (ulcers) as it is developing resistance to the current drugs. As far as the anti-carcinogenic property of Garcinol is concerned, it is particularly helpful in cases of intestinal, colorectal and pancreatic cancers. Garcinia Indica has also exhibited good anti-tumour activity against human leukaemia HL-60 cells. As an antioxidant, Garcinol is a voracious free radical scavenger and has been found to be beneficial against ulcers, which can be caused by Helicobacter pylori infection.
* A vast range of health benefits of various parts of Kokam justifies its exploration as a suitable functional food for neuroprotection in mental health disorders. Moreover, its isolated constituents such as garcinol, hydroxycitric acid, and Cyanidin-3-glucoside, were also effective in neuroprotection (Antala et al. 2012; Chen et al. 2009; Liao et al. 2005; Ohia et al. 2000).
* used as condiment in making many Indian cuisines (Yamaguchi et al. 2000).
*Yadav AV, Kawale LA, Nade VS. Effect of Morus alba L. (mulberry) leaves on anxiety in mice. Indian J Pharmacol. 2008;40:32–36. doi: 10.4103/0253-7613.40485.
*Yamaguchi F, Ariga T, Yoshimura Y, Nakazawa H. Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. J Agric Food Chem. 2000;48:180–185. doi: 10.1021/jf990845y.
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743703/
*https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462661/
[[Category:Treatments]]
[[Category:Herbal medicine]]