Difference between revisions of "Sophora flavescens"
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*Toxic effects from use of the root may include nausea, dizziness, vomiting, constipation, spasms, disturbance of speech, irregular breathing, respiratory failure and death. | *Toxic effects from use of the root may include nausea, dizziness, vomiting, constipation, spasms, disturbance of speech, irregular breathing, respiratory failure and death. | ||
==Health Benefits and Uses of Sophora flavescens== | ==Health Benefits and Uses of Sophora flavescens== | ||
| − | Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis | + | Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, Cancer, pyretic stranguria and viral hepatitis. |
| + | * Combats Cancer : Ku shen is a powerful multipurpose anti-cancer therapeutic agent that is strong alone at fighting cancer and can synergize with other chemo-therapies. For example, the main chemical from Kushen have been approved by Chinese FDA (CFDA) in 1995 as an anticancer drug to treat non-small cell lung cancer and liver cancer in combination with other anticancer drugs. Kushen has been used for: | ||
| + | **Bile Duct Cancer | ||
| + | **Bone Cancer | ||
| + | **Brain Cancer (neuroblastomas and glioblastomas) | ||
| + | **Breast Cancer (incl ER neg) | ||
| + | **Cervical Cancer | ||
| + | **Colon Cancer | ||
| + | **Gallbladder Carcinoma | ||
| + | **Leukemia | ||
| + | **Liver Cancer | ||
| + | **Lung Cancer | ||
| + | **Medulloblastoma | ||
| + | **Myeloid Leukemia | ||
| + | **Prostate Cancer (incl castration-resistant) | ||
| + | **Synovial Sarcoma | ||
| + | **Ku shen can also help with cisplatin resistant cancers. | ||
| + | * Reduces Pain : Ku shen can reduce pain symptoms associated with cancer, such as leukopenia and nausea. Ku shen can help reduce neuropathic pain (via NMDA). | ||
| + | * Improves Skin And Wound Healing : | ||
| + | **Ku shen can help with wound healing by increasing mRNA levels of growth factors such as IGF-1 and KGF in skin. | ||
| + | **Ku shen also helps with wound healing by pro-inflammatory cytokines such as PGE2 and IL-8. | ||
| + | **Ku shen may also help with dermatitis. | ||
| + | **Ku shen is commonly blended Scutellaria baicalensis, Rheum tanguticum, Dictamnus dasycarpus, Phellodendron chinense, and Kochia scoparia and used to treat skin inflammation. | ||
| + | **Ku shen can reduce melanin synthesis and may help improve skin whitening (via reduction of tyrosinase). | ||
| + | * Protects The Vascular System : Ku shen is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) , PDE4, and PDE3, thus making it useful for erectile dysfunction and overall vascular inflammation. For example, ku shen can combat atherosclerosis, a disease characterized by chronic vascular inflammation. Ku shen helps with blood flow and blood pressure by relaxing vascular smooth muscle (via NO-sGC-cGMP signaling).By regulating abnormal calcium-induced rhythms in the heart, ku shen can improve heart failure. Ku shen can also be therapeutic for septic shock‑induced heart injury. | ||
| + | * Combats Diabetes : Ku shen may be beneficial for metabolic diseases as it can activate peroxisome proliferator-activated receptors gamma and alpha (PPAR-gamma and PPAR alpha, respectively). For example, it can help with diabetes by reducing sodium-glucose linked transporter (SGLT) activity, thus helping remove excess glucose (hyperglycemia) through the kidneys. Ku shen can also act as inhibitors of a-glucosidase and b amylase, thus helping with glucose levels after eating starchy foods. Ku shen can also help with diabetes as it improves oral glucose tolerance, increases serum high density lipoprotein cholesterol (HDL-C) and reduces body weight, blood glucose levels and other related blood-lipid indexes (via increasing AMPK and GLUT4). | ||
| + | * Has Antimicrobial Properties against : Aggregatibacter actinomycetemcomitans, Escherichia coli, Fusobacterium nucleatum, Mycobacterium aurum, Prevotella intermedia, Porphyromonas gingivalis, Staphylococcus aureus, Streptococcus anginosus, Streptococcus criceti, Streptococcus gordonii, Streptococcus mutans, Streptococcus ratti, Streptococcus sanguinis, Streptococcus sobrinus R | ||
| + | * Ku shen has antiviral against : Cervical HPV, Coxsackievirus B3, HBV, Human type 1-3 reoviruses (HRV1-3), Influenza A Virus (H1N1), Korean porcine reovirus (PRV), Porcine circovirus type 2 (PCV2) R | ||
| + | Porcine reproductive respiratory syndrome virus (PRRSV). Ku shen also has properties to combat Flavi viruses (including Zika, Dengue and Hepatitis C virus). | ||
| + | |||
==References== | ==References== | ||
*''Kang SC, Lee CM, Choi H, et al. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res. 2006 Nov;20(11):1017-9.'' | *''Kang SC, Lee CM, Choi H, et al. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res. 2006 Nov;20(11):1017-9.'' | ||
Revision as of 03:16, 24 November 2019
Other names : Ku Shen Gen, Ku Shen, Bitter root, Yellow sophora root
Special Precautions of Sophora flavescens
- Patients with hormone-sensitive cancers should avoid taking S. flavescens as it demonstrated estrogenic effects in vitro, and can stimulate the proliferation of hormone-sensitive cancer cells.
- Toxic effects from use of the root may include nausea, dizziness, vomiting, constipation, spasms, disturbance of speech, irregular breathing, respiratory failure and death.
Health Benefits and Uses of Sophora flavescens
Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, Cancer, pyretic stranguria and viral hepatitis.
- Combats Cancer : Ku shen is a powerful multipurpose anti-cancer therapeutic agent that is strong alone at fighting cancer and can synergize with other chemo-therapies. For example, the main chemical from Kushen have been approved by Chinese FDA (CFDA) in 1995 as an anticancer drug to treat non-small cell lung cancer and liver cancer in combination with other anticancer drugs. Kushen has been used for:
- Bile Duct Cancer
- Bone Cancer
- Brain Cancer (neuroblastomas and glioblastomas)
- Breast Cancer (incl ER neg)
- Cervical Cancer
- Colon Cancer
- Gallbladder Carcinoma
- Leukemia
- Liver Cancer
- Lung Cancer
- Medulloblastoma
- Myeloid Leukemia
- Prostate Cancer (incl castration-resistant)
- Synovial Sarcoma
- Ku shen can also help with cisplatin resistant cancers.
- Reduces Pain : Ku shen can reduce pain symptoms associated with cancer, such as leukopenia and nausea. Ku shen can help reduce neuropathic pain (via NMDA).
- Improves Skin And Wound Healing :
- Ku shen can help with wound healing by increasing mRNA levels of growth factors such as IGF-1 and KGF in skin.
- Ku shen also helps with wound healing by pro-inflammatory cytokines such as PGE2 and IL-8.
- Ku shen may also help with dermatitis.
- Ku shen is commonly blended Scutellaria baicalensis, Rheum tanguticum, Dictamnus dasycarpus, Phellodendron chinense, and Kochia scoparia and used to treat skin inflammation.
- Ku shen can reduce melanin synthesis and may help improve skin whitening (via reduction of tyrosinase).
- Protects The Vascular System : Ku shen is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) , PDE4, and PDE3, thus making it useful for erectile dysfunction and overall vascular inflammation. For example, ku shen can combat atherosclerosis, a disease characterized by chronic vascular inflammation. Ku shen helps with blood flow and blood pressure by relaxing vascular smooth muscle (via NO-sGC-cGMP signaling).By regulating abnormal calcium-induced rhythms in the heart, ku shen can improve heart failure. Ku shen can also be therapeutic for septic shock‑induced heart injury.
- Combats Diabetes : Ku shen may be beneficial for metabolic diseases as it can activate peroxisome proliferator-activated receptors gamma and alpha (PPAR-gamma and PPAR alpha, respectively). For example, it can help with diabetes by reducing sodium-glucose linked transporter (SGLT) activity, thus helping remove excess glucose (hyperglycemia) through the kidneys. Ku shen can also act as inhibitors of a-glucosidase and b amylase, thus helping with glucose levels after eating starchy foods. Ku shen can also help with diabetes as it improves oral glucose tolerance, increases serum high density lipoprotein cholesterol (HDL-C) and reduces body weight, blood glucose levels and other related blood-lipid indexes (via increasing AMPK and GLUT4).
- Has Antimicrobial Properties against : Aggregatibacter actinomycetemcomitans, Escherichia coli, Fusobacterium nucleatum, Mycobacterium aurum, Prevotella intermedia, Porphyromonas gingivalis, Staphylococcus aureus, Streptococcus anginosus, Streptococcus criceti, Streptococcus gordonii, Streptococcus mutans, Streptococcus ratti, Streptococcus sanguinis, Streptococcus sobrinus R
- Ku shen has antiviral against : Cervical HPV, Coxsackievirus B3, HBV, Human type 1-3 reoviruses (HRV1-3), Influenza A Virus (H1N1), Korean porcine reovirus (PRV), Porcine circovirus type 2 (PCV2) R
Porcine reproductive respiratory syndrome virus (PRRSV). Ku shen also has properties to combat Flavi viruses (including Zika, Dengue and Hepatitis C virus).
References
- Kang SC, Lee CM, Choi H, et al. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res. 2006 Nov;20(11):1017-9.
- De Naeyer A, Vanden Berghe W, Pocock V, et al. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. J Nat Prod. 2004 Nov;67(11):1829-32.
- Yoo HH, Kim T, Ahn S, et al. Evaluation of the estrogenic activity of Leguminosae plants. Biol Pharm Bull. 2005 Mar;28(3):538-40.
- Bensky, Dan; Clavey, Steven; Stöger, Erich; Lai Bensky, Lilian (2015). Chinese Herbal Medicine: Materia Medica (Portable 3rd ed.). Seattle, USA: Eastland Press. pp. 575–578. ISBN 978-0-939616-82-4.
