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Coenzyme Q10

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See also : [[Ubiquinol]]<br>Other Names: Co Q10, Co Q-10, Coenzima Q-10, Co-Enzyme 10, Coenzyme Q 10, Coenzyme Q10, Co-Enzyme Q10, Co-Enzyme Q-10, Co-Q 10, CoQ10, Co -Q10, CoQ-10, Ubidcarenone, Ubidécarénone, Ubiquinone-10.<br>CoQ-10 is a nutrient produced by the “energy factories” in your cells called mitochondria. Coenzyme Q10 is a naturally-occuring compound found in every cell in the body. Coenzyme Q10's alternate name, Vitamin Qubiquinone, comes from the word ubiquitous, which means "found everywhere. The mineral [[selenium]] is essential for the body's natural production of Coenzyme Q10.
==Special Precautions of Coenzyme Q10==
* CoQ10 encourages blood clotting (a big no-no if you’re taking warfarin and other anti-coagulants), and can lower blood sugar and blood pressure to potentially dangerous levels. * It may also interfere with chemotherapy treatment.*CoQ10 and Statin Drugs : Some research suggests that statin drugs, or HMG-CoA reductase inhibitors, a class of drugs used to lower cholesterol, may interfere with the body's production of CoQ10. However, research on the use of CoQ10 supplements in people taking statins is still inconclusive, and it is not routinely recommended in combination with statin therapy.==The benefits of Coenzyme Q10 are==* High blood pressure or low blood pressure: Coenzyme Q -10 is normally associated with anti-ageing skin care productsmight lower blood pressure. It is an oilcan increase the effects of medications used to lower blood pressure. Discuss your use of coenzyme Q-soluble substance which demonstrates similar properties 10 with vitaminsyour healthcare provider if you have blood pressure problems. *Surgery: Coenzyme Q -10 naturally occurs in eukaryotic cells might interfere with blood pressure control during and is an important element of the electron transport chainafter surgery. Stop using coenzyme Q-10 at least two weeks before a scheduled surgery.* Coenzyme Q10 can potentially interfere with coumadin (Warfarin) and other blood-thinning medications.
==The benefits and uses of Coenzyme Q10 are==Coenzyme Q 10 is normally associated with anti-ageing skin care products. It is an oil-soluble substance which demonstrates similar properties with vitamins. Coenzyme Q 10 naturally occurs in eukaryotic cells and is an important element of the electron transport chain.The compound has been subjected to more than 5,000 clinical studies and its role in fighting the adverse effect of oxidative stress. As a person grows older, the body’s production of coenzyme Q 10 decreases. This makes the body more susceptible to disease like cancer and cardiovascular diseases. In Taking a study conducted to evaluate CoQ-10 supplement boosts the health benefits way your cells produce and use energy. It also helps your body burn fat, improves cholesterol ratios, boosts your physical energy levels and improves thyroid and pancreas functions. CoQ10 is fat-soluble. Take it with a bit of coenzyme olive oil or fish oil. Or have your CoQ10 with a meal that includes fish, dairy, eggs or meat. The powdered form of CoQ10 is more difficult to absorb. Try either gel caps or tablets and take them with some kind of fat.* Coenzyme Q -10deficiency. This is a very rare condition. The symptoms include weakness, researchers observed fatigue, and seizures.* Inherited or acquired disorders that cancer patients had lower levels limit energy production in the cells of the compound than healthier individualsbody (mitochondrial disorders). Coenzyme Improvement in symptoms is slow. Some people have to take coenzyme Q -10 for six months to get the most benefit.*Congestive heart failure (CHF). There is no evidence that taking coenzyme Q-10 alone can potentially help heart failure. But there is some evidence (though controversial) that it might be helpful when taken in strengthening the immune system combination with other heart failure medications and is also effective as a secondary treatment against cancertreatments. Numerous studies *Decreasing the risk of additional heart problems in people who have established had a recent heart attack (myocardial infarction, MI). When started within 72 hours of MI and gathered significant evidence taken for one year, coenzyme Q-10 appears to support significantly lower the health benefits risk of heart-related events including non-fatal MI.*Preventing blood vessel complications caused by heart bypass surgery. There is some evidence that taking coenzyme Q -10by mouth for a week before surgery might help to reduce blood vessel damage. This makes But not all research agrees with this finding.*High blood pressure (hypertension). Taking coenzyme Q-10 by itself or along with other medications for treating high blood pressure seems to help lower blood pressure even more.*Preventing migraine headache. Taking coenzyme Q-10 by mouth seems to help prevent migraine headaches. Studies show it one of can decrease the most significant frequency of headaches by about 30% and popular food supplements in the marketnumber of days with headache-related nausea by about 45% in adults. Though normally used as a topical treatment, the benefits Taking coenzyme Q-10 also appears to reduce migraine frequency in children who have low levels of coenzyme Q -10 . It can be better obtained through oral consumptiontake up to 3 months for significant benefit. I recommend the brand Jarrow FormulasUnfortunately, which is oil basedcoenzyme Q-10 doesn’t seem to be effective in treating migraines, once they have developed. This is important for *Parkinson’s disease. Some research shows that taking coenzyme Q-10 supplements might slow decline in people with early Parkinson’s disease. But taking a CoQ10 coenzyme Q-10 supplementin people with mid-stage Parkinson’s disease does not seem to improve symptoms.*Improving the immune system of people with HIV/AIDS. Coenzyme Q10 is a naturally*Muscular dystrophy, an inherited disorder involving muscle wasting. Taking coenzyme Q-occuring compound found 10 by mouth seems to improve physical performance in every cell in the bodysome patients with muscular dystrophy. Coenzyme Q10's alternate name, ubiquinone, comes from * strengthening the word ubiquitous, which means "immune system*Heart failure :People with heart failure have been found everywhereto have lower levels of CoQ10 in heart muscle cells."*Cardiomyopathy :Several small trials have found CoQ10 may be helpful for certain types of cardiomyopathy.*Parkinson's disease : Lower levels of CoQ10 plays a key role in producing energy have also been observed in people with Parkinson's disease. Preliminary research has found that increasing CoQ10 may increase levels of the mitochondrianeurotransmitter dopamine, the part of which is thought to be lowered in people with Parkinson's disease. It has also been suggested that CoQ10 might protect brain cells from damage by free radicals.* Cancer : In a cell responsible for study conducted to evaluate the production health benefits of energy in the form coenzyme Q 10, researchers observed that cancer patients had lower levels of ATPthe compound than healthier individualsWhy People Use Coenzyme Q10 *Heart failure*Cardiomyopathy
*Heart Attack Prevention and Recovery
*High Blood Pressure
*Migraine
*Counteract Prescription Drug Effects
*Parkinson's disease
*Weight loss
*eliminates depression and anxiety
*Huntington’s disease (a rare genetic neurological disorder). Ubiquinol, an altered form of coenzyme Q-10, has been granted “Orphan Drug Status” by the Federal Food and Drug Administration (FDA). This gives the maker of Ubiquinol some financial incentives to study its effectiveness for Huntington’s, a condition that is so rare (affecting less than 200,000 individuals) that pharmaceutical companies might not otherwise invest in developing a drug for it. However, taking coenzyme Q-10 by mouth in doses of 600 mg per day or less doesn’t seem to be effective for slowing the progression of Huntington’s disease.
What is the Evidence For Coenzyme Q10?== Food sources ==
*Heart failure{| class="wikitable"People with heart failure have been found to have lower |+ CoQ<sub>10</sub> levels of CoQ10 in selected foods ! Food !! Coenzyme Q<sub>10</sub> concentration [mg/kg]|-!Beef|-|heart || 113|-|liver||39–50|-|muscle cells. Double||26–40|-blind research suggests that CoQ10 may reduce symptoms related to !Pork|-|heart failure, such as shortness of breath, difficulty sleeping, and swelling||11. CoQ10 is thought to increase energy production in the heart muscle, increasing the strength of the pumping action8–128. Recent human studies, however, haven't supported this.In one study, 641 people with congestive heart failure were randomized to receive either CoQ10 (2 mg per kg body weight) or a placebo plus standard treatment|-|liver ||22. People who took the CoQ10 had a significant reduction in symptom severity and fewer hospitalizations7–54.In another study, 32 patients with end0|-stage heart failure awaiting heart transplantation received either 60 mg of CoQ10 or a placebo for 3 months|muscle ||13. Patients who took the CoQ10 experienced a significant improvement in functional status, clinical symptoms, and quality of life, however there were no changes in echocardiogram (heart ultrasound) or in objective markers8–45.A study randomized 55 patients with congestive heart failure to receive either 200 mg per day of CoQ10 or a placebo in addition to standard treatment. Although serum levels of CoQ10 increased in patients receiving CoQ10, CoQ10 didn't affect ejection fraction, peak oxygen consumption, or exercise duration.A longer0|-term study investigated the use of 100 mg of CoQ10 or a placebo in addition to standard treatment in 79 patients with stable chronic congestive !Chicken|-|heart failure||116. The results indicated that CoQ10 only slightly improved maximal exercise capacity and quality of life compared with the placebo2–132.2*Cardiomyopathy|-Several small trials have found CoQ10 may be helpful for certain types of cardiomyopathy.!Fish*Parkinson's disease : Lower levels of CoQ10 have also been observed in people with Parkinson's disease. Preliminary research has found that increasing CoQ10 may increase levels of the neurotransmitter dopamine, which is thought to be lowered in people with Parkinson's disease. It has also been suggested that CoQ10 might protect brain cells from damage by free radicals.A small, randomized controlled trial examined the use of 360 mg CoQ10 or a placebo in 28 treated and stable Parkinson's disease patients. After 4 weeks, CoQ10 provided a mild but significant significant mild improvement in early Parkinson's symptoms and significantly improved performance in visual function.A larger 16 month trial funded by the National Institutes of Health explored the use of CoQ10 (300, 600 or 1200 mg|-|sardine ||5–64|-|mackerel|-|red flesh ||43–67|-|white flesh ||11–16|-|salmon ||4–8|-|tuna ||5|-!Oils|-|soybean ||54–280|-|olive ||4–160|-|grapeseed ||64–73|-|sunflower ||4–15|-|rice bran ||/day) or a placebo in 80 patients with early stage Parkinson's disease. The results suggested that CoQ10, especially at the 1200 mg per day dose, had a significant reduction in disability compared |-|coconut |||-!Nuts|-|peanuts ||27|-|walnuts ||19|-|sesame seeds ||18–23|-|pistachio nuts ||20|-|hazelnuts ||17|-|almond ||5–14|-!Vegetables|-|parsley ||8–26|-|broccoli ||6–9|-|cauliflower ||2–7|-|spinach ||up to those who took a placebo.10|-|grape ||6–7|-|Chinese cabbage ||2–5|-!Fruit|-|avocado ||10|-|blackcurrant ||3|-|strawberry ||1|-|orange ||1–2|-|grapefruit ||1|-|apple ||1|}
Meat and fish are the richest source of dietary CoQ<sub>10</sub> and levels over 50&nbsp;mg/kg can be found in beef, pork and chicken heart, and chicken liver. Dairy products are much poorer sources of CoQ<sub>10</sub> compared to animal tissues. Vegetable oils are also quite rich in CoQ<sub>10</sub>. Within vegetables, parsley, and perilla are the richest CoQ<sub>10</sub> sources, but significant differences in their CoQ<sub>10</sub> levels can be found in the literature. [[Broccoli]], grape, and cauliflower are modest sources of CoQ<sub>10</sub>. Most fruit and berries represent a poor to very poor source of CoQ<sub>10</sub>, with the exception of [[avocado]], with a relatively high CoQ<sub>10</sub> content.
* The mineral [[selenium]] is essential for the body's natural production of Coenzyme Q10.
*cholesterol-lowering drugs -- actually deplete your body’s natural CoQ-10. Statins block production of cholesterol in the liver, where CoQ-10 is also manufactured. Without sufficient CoQ-10, statins can cause liver damage ... irregular heartbeat ... muscle weakness ... leg cramps ... heart attack and stroke (the two potentially fatal conditions that statins are supposed to prevent).
*Other medications also can limit your body’s production of CoQ-10, including: Diabetes drugs ... antidepressants ... female hormone replacement therapy ... and blood pressure meds. If you take any of these, you definitely need to supplement with CoQ-10.
*When shopping, labels may read “CoQ-10” or “Coenzyme Q-10”, but the more active form will be labeled “QH” or “ubiquinol.” This is a stronger form of CoQ-10, though purchasing that version isn’t essential, especially if price is an issue. Take 100 mg two or three times twice per day, because your body can’t metabolize higher doses.
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