*Do not use if you have hypertension, hypokalemia edema, cirrhosis of the liver, cholestatic liver disorder, and diabetes.
* Long-term use of licorice can lead to fluid retention, increased blood pressure, loss of potassium and lowered libido as it contains [[isoflavones]] ([[phytoestrogens]]). It might lower the amount of serum testosterone slightly.
* licorice may reduce levels of the hormone testosterone in men. After one week of treatment with licorice, testosterone levels decreased 26%.
* Pregnant women should not use licorice at medicinal doses. There is a danger of high blood pressure or of a hormone imbalance that would harm the fetus.
* Anyone with a heart problem should use licorice only under medical supervision. Potassium depletion caused by licorice is especially hazardous for such patients. Anyone with pre-existing hypokalemia (low potassium) should not take licorice.