Difference between revisions of "African trypanosomiasis"
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* It has also been reported by Moideen et al. (1999) that extracts of the stem bark and root bark of Kigelia pinnata possess marked anti-trypanosomial activity against bloodstream forms of both T. b. brucei and T. b. rhodesiense. | * It has also been reported by Moideen et al. (1999) that extracts of the stem bark and root bark of Kigelia pinnata possess marked anti-trypanosomial activity against bloodstream forms of both T. b. brucei and T. b. rhodesiense. | ||
==references== | ==references== | ||
− | * ''Bodley A L, Shapiro T A (1995). Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania. Proceedings of the National Academy of Science of the USA, 92:3726-3730. | + | * ''Bodley A L, Shapiro T A (1995). Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania. Proceedings of the National Academy of Science of the USA, 92:3726-3730.'' |
− | Hoet S, Opperdoes F, Brun R, Quetin-Leclercq J (2004). Natural products active against African trypanosomes: a step towards new drugs. Natural Product Reports, 21: 353-364.'' | + | * ''Hoet S, Opperdoes F, Brun R, Quetin-Leclercq J (2004). Natural products active against African trypanosomes: a step towards new drugs. Natural Product Reports, 21: 353-364.'' |
* ''Freiburghaus F, Ogwal EN, Nkunya MH, Kaminsky R, Brun R (1996). In vitro antitrypanosomal activity of African plants used in traditional medicine in Uganda to treat sleeping sickness. Tropical Medicine and International Health, 1(6):765-771.'' | * ''Freiburghaus F, Ogwal EN, Nkunya MH, Kaminsky R, Brun R (1996). In vitro antitrypanosomal activity of African plants used in traditional medicine in Uganda to treat sleeping sickness. Tropical Medicine and International Health, 1(6):765-771.'' | ||
* ''Maikai VA, Abubakar U, Salman AA, Inuwa TN (2010). Preliminary Survey of Medicinal Plants Used in Treatment of Animal Trypanosomiasis in Kaduna State, Nigeria. Ethnobotanical Leaflets, 14: 319-326.'' | * ''Maikai VA, Abubakar U, Salman AA, Inuwa TN (2010). Preliminary Survey of Medicinal Plants Used in Treatment of Animal Trypanosomiasis in Kaduna State, Nigeria. Ethnobotanical Leaflets, 14: 319-326.'' | ||
*'' Moideen SVK, Houghton PJ, Rock P, Croft SL, Aboagye-Nyame F (1999). Activity of extracts and naphthoquinones from Kigelia pinnata against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Planta Medica, 65(6):536-540.'' | *'' Moideen SVK, Houghton PJ, Rock P, Croft SL, Aboagye-Nyame F (1999). Activity of extracts and naphthoquinones from Kigelia pinnata against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Planta Medica, 65(6):536-540.'' |
Revision as of 12:19, 23 April 2017
Natural Treatment
- Trichilia emetica
- Strychnos spinosa
- Hymenocardia acida
- Plants such as Khaya senegalensis and Terminalia avicenniodes are used in the treatment of trypanosomosis in animals (Maikai et al., 2010).
- Studies have also shown that extracts of Albizia gummifera, Ehretia amoena , Entada abyssinica, Securinega virosa and Vernonia subuligera have anti-trypanosomial activity (Freiburghaus et al., 1996).
- Quinoline alkaloids obtained from Cinchona bark and emetine, an isoquinoline alkaloid obtained from Cephaelis ipecacuanha (Hoet et al, 2004), as well as camptothecin , a pentacyclic alkaloid from Camptotheca acuminata (Nyssaceae), have all demonstrated promising anti- trypanosomial activity (Bodley and Shapiro, 1995).
- It has also been reported by Moideen et al. (1999) that extracts of the stem bark and root bark of Kigelia pinnata possess marked anti-trypanosomial activity against bloodstream forms of both T. b. brucei and T. b. rhodesiense.
references
- Bodley A L, Shapiro T A (1995). Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania. Proceedings of the National Academy of Science of the USA, 92:3726-3730.
- Hoet S, Opperdoes F, Brun R, Quetin-Leclercq J (2004). Natural products active against African trypanosomes: a step towards new drugs. Natural Product Reports, 21: 353-364.
- Freiburghaus F, Ogwal EN, Nkunya MH, Kaminsky R, Brun R (1996). In vitro antitrypanosomal activity of African plants used in traditional medicine in Uganda to treat sleeping sickness. Tropical Medicine and International Health, 1(6):765-771.
- Maikai VA, Abubakar U, Salman AA, Inuwa TN (2010). Preliminary Survey of Medicinal Plants Used in Treatment of Animal Trypanosomiasis in Kaduna State, Nigeria. Ethnobotanical Leaflets, 14: 319-326.
- Moideen SVK, Houghton PJ, Rock P, Croft SL, Aboagye-Nyame F (1999). Activity of extracts and naphthoquinones from Kigelia pinnata against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Planta Medica, 65(6):536-540.