Changes

analyzing the essential oil was evaluated. The results clearly show the analgesic and anti-inflammatory antiinflammatory effects of theplant essential oil and hydroalcoholic extract. Further studies are needed to clarify the mechanism of action and thecomponents responsible for these pharmacological effects (21).* Anticonvulsant: The anticonvulsant activity of acetone extract of the seeds of Heracleum persicum (Umbelliferae) was examinedagainst pentylenetetrazole. The extract showed a dose-dependent protective effect in both seizure models. However,the sedative dose of the extract, examined by rotarod test, was close to the anticonvulsant doses. Preliminaryphytochemical analysis showed the presence of alkaloids, terpenoids, triterpenes and steroids in the extract. Theobserved pharmacological effects could be due to alkaloids, terpenoids and triterpenes present in the plant .==References== * Coruh N, Celep AS, Özgökçe F. Food chem . 2007;100(403):1237-42. * Hajhashemi V, Sajjadi SE, Heshmati M. J ethnopharmacol. 2009;124(3):475-80. * Panahi Y, Pishgoo B, Sahebkar A.heart views. 2015;16(3):85.* Panahi Y, Dadjou Y, Pishgoo B, Akbari A, Sahebkar A.J Diet Suppl. 2016;13(5):530-7.* Souri E, Farsam H, Sarkheil P, Ebadi F. Pharm Biol. 2008.* Nejad BS, Rajabi M, Mamoudabadi AZ, Zarrin M.Jundishapur J Microbiol. 2014;7(1).* Dadjo Y, Panahi Y, Pishgoo B, Sahebkar A, Taghipour H, Akbari A, et al. Phytother Res. 2015;29(1):141-3.* Hajhashemi V, Dashti G, Saberi S, Malekjamshidi P.Avicenna J Phytomed. 2014;4(3):144.* Sayyah M, Moaied S, Kamalinejad M. J ethnopharmacol. 2005;98(1):209-11.