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* [[Shiitake]] AHCC (active hexose correlated compound) is a natural substance extracted from certain species of basidiomycetes (a class of mushrooms that includes [[shiitake]]). Polysaccharides comprise 40% of the composition of AHCC. These include [[beta glucan]] (β-glucan) and acetylated α-glucan. Acetylated α-glucan, produced by culturing the mushroom mycelia, is unique to AHCC. Glucans are polysaccharides and these polysaccharides are known to have immune stimulating effects While research on AHCC's heath health effects is fairly limited, proponents claim that taking AHCC can produce a variety of health benefits.

*Little is known about the safety of long-term use of AHCC. However, there's some concern that AHCC may trigger mild side effects, including diarrhea and itching.*Human studies have reported AHCC dose-related toxicities such as nausea, diarrhea, bloating, headache, fatigue, and foot cramps.*AHCC may lower blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar levels. Blood glucose levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.*AHCC may affect the risk of bleeding when taken with agents that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).*Use cautiously in patients with autoimmune diseases or those who are using drugs that affect the immune system. Also use cautiously in patients with skin disorders, muscle or joint disorders, or fever.*AHCC may interfere with agents metabolized by the CYP450 2D6 enzyme system.

[[Category:Xpolysaccharides]]