* Taking large amounts of black and white pepper by mouth, which can accidentally get into the lungs, has been reported to cause death. This is especially true in children.
* Pregnancy and breast-feeding: It’s OK to use black and white pepper in food amounts if you are pregnant. But taking larger amounts might be unsafe. There is concern that black pepper in large amounts might trigger a miscarriage. Also, avoid putting pepper on your skin. Not enough is known about the safety of using topical pepper during pregnancy.If you are breast-feeding, limit pepper intake to food amounts. Not enough is known about the safety of using larger medicinal amounts.
* Cancer : There is conflicting evidence about their role in cancer. Some evidence suggests pepper might protect against colon cancer, but other evidence suggests it might promote liver cancer.
* Lithium interacts with BLACK PEPPER AND WHITE PEPPER
* Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BLACK PEPPER AND WHITE PEPPER.