Serrapeptase

Other names : Butterfly Enzyme, Enzyme de Ver de Soie, Extrait de Ver de Soie, SER, Serratia peptidase, Serratiopeptidase, Silk Worm Enzyme, Silkworm Extract, Serra enzyme, Serratiopeptidase, Serratio peptidase, serrazyme, serra peptase, serrapeptidase, serra enzyme, serraplus)
See also :

• Enzymes
• Proteolytic Enzymes
• Fibrinolytic Enzymes

Serrapeptase is a proteolytic enzyme (breaks down proteins) isolated from a bacteria called Serratia E15 which is found in the intestines of silk worm. In the silkworm this enzyme helps them off to dissolve the cocoon (which if you have ever seen one is hard as rock).

Special Precautions of Serrapeptase

• Serrapeptase reduces the elasticity and thickness of nasal mucus secretions as well as fluids that are produced around the site of an injury. Since mucus is thinned, serrapeptase may well help people suffering from diseases like cystic fibrosis, chronic bronchitis, bronchial asthma, pulmonary tuberculosis, emphysema and sinus issues etc.
• Bleeding disorders: Serrapeptase might interfere with blood clotting, so some researchers worry that it might make bleeding disorders worse. If you have a bleeding disorder, check with your healthcare provider before using serrapeptase.
• Surgery: Serrapeptase might interfere with blood clotting. There is a concern that it might increase bleeding during and after surgery. Stop using serrapeptase at least 2 weeks before a scheduled surgery.
• Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with SERRAPEPTASE

The benefits of Serrapeptase are

Serrapeptase has been called the “miracle enzyme” or the “super enzyme” due to its wide range of actions in human body and the fact that it’s got no reported side-effects. It’s been used for more than three decades throughout Europe and Asia for a variety of treatments and is seen as a natural alternative to anti-inflammatory drugs. It is widely used in clinical practice throughout Japan. There are some amazing stories about this enzyme that the one that caught my attention most was the story of Mike Tawse who was born with spastic diplegia (cerebral palsy). Cell studies have shown that serrapeptase has strong anti-inflammatory effects which has made it supplement that is often given to arthritis sufferers. It can digest non-living tissue including cysts and blood clots (as reported by the late Dr. Hans Alfred Nieper).Serrapeptase is often taken to treat inflammatory bowel disease, arthritis, sinusitis and fibrocystic breast disease. Research suggests that it helps to break up fibrin – a protein mesh produced by the body in response to injury. Fibrin helps blood cells clot around an injury and develops into scar tissue. However, blood clots can also form in arteries, leading to heart attacks, strokes and the deep vein thrombosis we hear so much about on the TV these days. It serrapeptase can help reduce levels of access fibrin then perhaps it can help prevent dangerous blood clots forming. Serrapeptase reduces the growth of bradykinins (compounds that bind to sites of inflammation) to help reduce swelling. It is therefore used to help reduce pain and inflammation in the following disorders:

• Fibrocystic breast disease
• Ear infections
• Nose infections
• Throat infections
• Post surgical edema : A small study published in the International Journal of Oral and Maxillofacial Surgery in 2008 suggests that serrapeptase may help alleviate pain and swelling resulting from dental surgery. The study involved 24 healthy people, all of whom underwent surgical removal of impacted molars. Compared to those who were given a placebo in combination with pain medication, participants who received both serrapeptase and pain medication experienced significantly less pain and cheek swelling in the seven days following surgery.
• Carpal tunnel syndrome : Serrapeptase may help manage carpal tunnel syndrome, according to a small study published in The Journal of the Association of Physicians of India in 1999. For the study, 20 carpal tunnel syndrome patients were given 10 mg of serrapeptase twice daily. After six weeks of treatment, 65 percent of cases showed significant improvement.
• Breast Engorgement : For a study published in Singapore Medical Journal in 1989, researchers assigned 70 women with breast engorgement to three days of treatment with either a placebo or serrapeptase. (Very common among breastfeeding women, breast engorgement is a painful condition that occurs when the breasts overfill with milk.) Study results revealed that serrapeptase was superior to the placebo in terms of its effects on breast pain and swelling.
• Chronic airway disease
• Reducing inflammation and pain after dental surgery.
• Reducing levels of neutrophils in the blood which can help treat respiratory disorders.
• Thinning sputum to help reduce the chance of mucus accumulation.
• Reducing post-operative pain, inflammation and swelling.
• Helpful in treating heart related conditions, like treating arterial plaque and reversing atherosclerosis to help protect patients against heart attacks and stroke.
• Dissolve harmful substances that form plaque in the arterial walls like cellular waste, fat, fibre in, cholesterol and calcium.
• Dr. Arnold Renshaw treated 700 patients with fibrositis, rheumatoid arthritis or osteoarthritis and had excellent results, taking around two months to start showing signs of recovery. He also found serrapeptase was effective in patients with Still’s disease and Ankylosing Spondylitis.
• Some manufacturers claim that taking serrapeptase in combination with nattokinase can help treat arthritis, enhance heart health, stimulate the immune system, and reduce inflammation. However, there is currently a lack of scientific evidence to support this claim.

References

• Al-Khateeb TH, Nusair Y. "Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars." Int J Oral Maxillofac Surg. 2008 Mar;37(3):264-8.
• Hirahara K, Saitoh T, Terada I, Uno K, Nagai A, Kioi S, Arakawa M. "A case of pneumonitis due to serrapeptase." Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Oct;27(10):1231-6.
• Kee WH, Tan SL, Lee V, Salmon YM. "The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial." Singapore Med J. 1989 Feb;30(1):48-54.
• Nirale NM, Menon MD. "Topical formulations of serratiopeptidase: development and pharmacodynamic evaluation." Indian J Pharm Sci. 2010 Jan;72(1):65-71.
• Panagariya A, Sharma AK. "A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome." J Assoc Physicians India. 1999 Dec;47(12):1170-2.
• Sasaki S, Kawanami R, Motizuki Y, Nakahara Y, Kawamura T, Tanaka A, Watanabe S. "Serrapeptase-induced lung injury manifesting as acute eosiniphilic pneumonia." Nihon Kokyuki Gakkai Zasshi. 2000 Jul;38(7):540-4.

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