Changes

producing substance.

* CANCER : As early as 1997, researchers have proposed to use resveratrol as a cancer-preventive agent. Resveratrol was shown to have anti-cancer activities in assays representing three major stages of carcinogenesis.Resveratrol has been shown to inhibit cancer initiation and promotion. It acts as a selective estrogen receptor modulator (SERM) and regulates proteins involved in DNA synthesis and cell cycle. Resveratrol also affects the activity of transcriptional factors involved in proliferation and stress responses, such as NF-kB, AP1 and Egr1.Researchers from researchers at Cook County Hospital found that gastric adenocarcinoma cells respond to resveratrol treatment with suppression of DNA synthesis, activation of nitric oxide synthase, induction of apoptosis and inhibition of total PKC and PKC alpha activity. Resveratrol adds to the growth inhibitory/anticancer activity of cisplatin and doxorubicin in vitro and protects against doxorubicin-induced cardiac toxicity both in vitro and in mice. Researchers found that high-doses of resveratrol triggered apoptosis in five out of six uterine cancer cell lines. Resveratrol exhibited a variety of molecular events in etoposide-based combination therapy in HT-29 colon cancer cells. Resveratrol also induced growth inhibition in T47D human breast cancer cells. Researchers from China Medical University, Taiwan, found resveratrol significantly inhibited growth factor heregulin-beta1 (HRG-beta1)-mediated Matrix metalloproteinase (MMP-9) expression in human breast cancer cells. Resveratrol significantly reduced the incidence of poorly differentiated prostatic adenocarcinoma by 7.7-fold in an animal study. A microarray gene expression study suggested that resveratrol is a potent inhibitor of A549 lung cancer cell growth. However, a phase I study suggests that consumption of high-dose resveratrol might be insufficient to elicit systemic levels commensurate with cancer preventive efficacy. http://www.zhion.com/phytonutrients/Resveratrol_Cancers.html

*[[Cardiovascular Disease]] : Resveratrol is a phytoestrogen, potent antioxidant, reactive oxygen species scavenger and metal chelators. Thus, it may have benefits of protection of the cardiovascular system against ischemic-reperfusion injury; it may also protect and maintain the intact endothelium, exhibits antiatherosclerotic properties inhibits the LDL oxidation, suppress the platelet aggregation and exhibits estrogen like action.

*[[Hyperglycemia (High Blood Sugar)]], a symptom of diabetes mellitus, induces hyperosmotic responses, including apoptosis, in vascular endothelial cells and leukocytes. Hyperosmotic shock elicits a stress response in mammalian cells, often leading to apoptotic cell death. Moreover, resveratrol was found to attenuate high glucose-induced apoptotic changes by virtue of its antioxidant property.Resveratrol administration ameliorates common DM symptoms, such as body weight loss, polyphagia, and polydipsia. In STZ-nicotinamide DM rats, resveratrol administration significantly decreased insulin secretion and delayed the onset of insulin resistance.Researchers, at Boston University Medical Center, revealed inactivation of hepatic AMP-activated protein kinase was a key event in the pathogenesis of hyperlipidemia in diabetes (based on a study of in type 1 diabetic LDL receptor-deficient mice). They showed that resveratrol could lower lipid levels by activating AMP-activated protein kinase. It was about 200 times the potency of Metformin! http://www.zhion.com/phytonutrients/Resveratrol_Diabetes.html

* Fatty Liver : The prevalence of nonalcoholic fatty liver disease is high.nonalcoholic fatty liver disease is linked to obesity, diabetes mellitus, and hypertriglyceridemia.Approximately 20% of patients with nonalcoholic fatty liver disease will eventually develop cirrhosis. Resveratrol was found to decrease nonalcoholic fatty liver disease severity in rats. This effect was mediated, at least in part, by tumor necrosis factor alpha (TNF-alpha) inhibition and antioxidant activities.

* [[Pancreatitis]] : Because microcirculation occlusion and cytokines over-production is involved in many diseases such as acute pancreatitis, resveratrol as a platelet and cytokines inhibitor may have benefits on acute pancreatitis.

* Liver transplant : Resveratrol has been shown to have an immuno-suppressive property as well as protective effect on hepatocytes under allograft rejection in a study of Wistar rats.