Chlorogenic Acid
From Wikiwel
Other names : dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexanecarboxylic acid, 3-(3,4-Dihydroxycinnamoyl)quinate, 3-(3,4-Dihydroxycinnamoyl)quinic acid, 3-Caffeoylquinate, 3-Caffeoylquinic acid, 3-CQA, 3-O-Caffeoylquinic acid, Chlorogenate, Chlorogenic acid, Heriguard, 3-trans-Caffeoylquinic acid
See also :
Special Precautions of Chlorogenic Acid
- It was hypothesized in the 1960′s that chlorogenic acid was a chemical sensitizer, responsible for causing respiratory allergies to certain plant materials containing chlorogenic acid in humans. Some experiments on animals using fairly aggressive techniques, did cause severe allergic reactions after the material was injected into the animals, both to sensitise them and again to elicit the allergic response.
- Chlorogenic acid has also been associated with increased levels of the protein amino acid homocysteine. Increased homocysteine levels are linked to an increase in the risk of cardiovascular disease, however, it has not been proven that reducing elevated homocysteine improves cardiovascular outcomes for people.
- Chlorogenic acid and caffeic acid were once thought to be capable of inducing vitamin B1 deficiency, however, this hypothesis was disproven in the early 1980′s. It can however, reduce the absorption of zinc and iron from the diet.
Benefits and uses of Chlorogenic Acid are
- Slowed glucose absorption, reduced insulin spike after eating : slow down the absorption of glucose in the human gut, therefore reducing the insulin spike after a meal, an effect that is of significant benefit to those suffering from type II diabetes, insulin resistance, metabolic syndrome or polycystic ovarian syndrome.
- Reduced production of glucose in the liver : Chlorogenic acid has also been found in vitro to inhibit the liver enzyme glucose-6-phosphatase which plays a critical role in the production of glucose in the liver.
- Increased uptake of glucose in muscle tissue
- Reduced risk of type II diabetes : People who drink a significant amount of coffee have less of a risk of developing type II diabetes than non-coffee drinkers. As caffeine worsens insulin sensitivity, this effect has been attributed to chlorogenic acid.
- Protection against Alzheimer’s disease, nerve degeneration : Population studies have linked moderate coffee consumption with a reduced risk of neurodegenerative diseases and laboratory studies have begun to confirm that chlorogenic acid is one of the agents responsible for this protective effect, although caffeine is also considered likely to have a protective effect.
- Reduced risk of liver disease : The results of epidemiological research suggest that coffee consumption may help prevent several chronic diseases, including cirrhosis of the liver and hepatocellular carcinoma (liver cancer) as well as gallstones.
- Reduced body mass and fat
- Increase fat-burning and inhibit new fat cells forming
- Mild laxative
- Lower blood pressure
- Stimulant : Chlorogenic acid has a weak psychostimulant effect, with animal studies in rats estimating the effect to be around one third as strong as the effect from caffeine.
- Improve mood and cognitive abilities : A 2012 study in healthy elderly participants found that decaffeinated coffee with a higher concentration of chlorogenic acids (521 mg) improved their mood and ability to perform a battery of cognitive tasks in comparison with ordinary decaffeinated coffee which contained only 224 mg chlorogenic acids.
- Eyesight : Chlorogenic acid found in coffee prevents cell death in the retina by at least 73%. In some cases, it didn't just prevent cell damage—it actually increased the number of healthy cells.
Food Sources
- Isomers of chlorogenic acid are found in potatoes.
- Chlorogenic acid can be found in bamboo Phyllostachys edulis as well as in many other plants. It is one of the major phenolic compounds identified in peach and in prunes. It also is one of the phenols found in green coffee bean extract.
- Chlorogenic acid, its 3-O-glucoside, 3-O-galactoside and 3-O-arabinoside can be found in the shoots of Calluna vulgaris (heather).
