Indole-3-carbinol

Other Names: 3-Hydroxymethyl Indole, 3 Hydroxymethyl Indole, I3C, Indole 3 Carbinol, 3-(hydroxymethyl), 3-(hydroxyméthyl), 3 (hydroxymethyl) Indole, 3-Indolylcarbinol, 3 Indolylcarbinol, 3-Indolylmethanol, 3 Indolylmethanol, Indol-3-Carbinol, Indole, Indole 3 Carbinol, Indole-3-methanol, Indole-3-méthanol.
Indole-3-carbinol is a substance found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. It can also be produced in the laboratory.
See also : Cruciferous Vegetables

Special Precautions of Indole-3-carbinol

• Indole-3-carbinol is likely safe for most people when used in amounts typically found in the diet. It seems to be safe for most people when used in medicinal amounts under proper medical supervision. It can cause side effects such as skin rashes and small increases in liver enzymes.
• In very high doses, indole-3-carbinol can cause balance problems, tremor, and nausea.
• Pregnancy and breast-feeding: If you are pregnant or breast-feeding, stick with indole-3-carbinol in amounts typically found in the diet. Not enough is known about the safety of using indole-3-carbinol in larger medicinal amounts.
• Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with INDOLE-3-CARBINOL

Health Benefits and uses of Indole-3-carbinol are

• Cancer Prevention : Researchers are interested in indole-3-carbinol for cancer prevention, particularly breast, cervical and endometrial, and colorectal cancer. Their reason is that diets with higher amounts of fruit and vegetable consumption are associated with a decreased risk of developing cancer. Researchers suspect indole-3-carbinol is one of several vegetable components that might protect against cancer.
• cervical dysplasia : Abnormal development and growth of cells of the cervix.