Lupeol

Other Names : Fagarsterol, Fagarasterol; Farganasterol (3β,13ξ)-Lup-20(29)-en-3-ol; Clerodol; Monogynol B
is a triterpene (phytosterol)

Benefits and uses of Flavonoids are

• anti-inflammatory : Lupeol has been the subject of many investigations and clinical trials during the last 15 years in order to verify its claimed beneficial properties, among which we have to highlight its immense anti-inflammatory properties, a process known to be directly linked to many types of cancer and a precursor of some tumors.
• Prostate Cancer : Lupeol has also shown to be able to decrease serum prostate-specific antigen (PSA) levels and inhibit the tumorigenicity of prostate cancer (CaP) cells in vivo.
• Orale Cancer : Researchers from Hong Kong University published an article in the ‘Journal of Cancer Research’ noting that blueberries, papaya, and blackberries potentially reduce the risk of developing oral cancer. Lupeol is a triterpene compound abundantly found in these fruits and exhibits anti-cancer properties by blocking NFkB, a naturally occurring protein, which assists cell growth. The study concluded that lupeol suppresses the spread of cancer and reduces tumor size three times faster than cisplatin (a platinum-based chemotherapy drug). Also, lab tests indicate that lupeol does not induce weight loss.
• head and neck cancers, according to a study conducted by researchers at the University of Hong Kong.

Food Sources

• vegetables :
  • green pepper
  • white cabbage
  • pepper
  • cucumber
  • tomatoes
  • red grapes
  • mangoes (Mangifera indica)
  • Japanese pear (Shinko)
  • Papaya
  • grapes
  • olives
  • figs
  • three leaved caper (Crataeva nurvala)
  • strawberries.
• Plants :
  • American ginseng
  • Elm plant
  • Aloe leaves
  • Shea butter plant
  • Tamarindus indica
  • Allanblackia monticola
  • Himatanthus sucuuba
  • Celastrus paniculatus
  • Zanthoxylum riedelianum
  • Leptadenia hastata
  • Crataeva nurvala
  • Bombax ceiba
  • Sebastiania adenophora
  • Acacia visco
  • Abronia villosa
  • Dandelion coffee.
    

References

• Lupeol, A Novel Anti-inflammatory and Anti-cancer Dietary Triterpene Mohammad Saleem* Mohammad Saleem, School of Medicine and Public Health, University of Wisconsin, Madison, WI; * Correspondence : Mohammad Saleem, Bhat , PhD, School of Medicine and Public Health 1300 University Avenue MSC-B25, Lab # 4385 University of Wisconsin-Madison Madison, WI, 53719, USA
• Lupeol inhibits proliferation of human prostate cancer cells by targeting β-catenin signaling Mohammad Saleem,† Imtiyaz Murtaza,† Rohinton S. Tarapore,1 Yewseok Suh, Vaqar Mustafa Adhami, Jeremy James Johnson,2 Imtiaz Ahmad Siddiqui, Naghma Khan, Mohammad Asim, Bilal Bin Hafeez, Mohammed Talha Shekhani, Benyi Li,3 and Hasan Mukhtar corresponding author Department of Dermatology, University of Wisconsin, 1300 University Avenue, MSC-25B, Madison, WI 53706, USA 1Molecular and Environmental Toxicology Center 2School of Pharmacy, University of Wisconsin, Madison, WI 53706 3Department of Urology, 2045 Lied Biomedical Research Facility, University of Kansas Medical Center, Mail Stop 3035, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA corresponding authorCorresponding author.
• Lupeol Triterpene, A Novel Diet-based Microtubule Targeting Agent: Disrupts Survivin/cFLIP Activation in Prostate Cancer Cells. Mohammad Saleem,* Imtiyaz Murtaza, Olya Witkowsky, and Amanda Marie Kohl School of Medicine and Public Health, University of Wisconsin, Madison, WI