Difference between revisions of "Phycocyanin"
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Phycocyanin is light harvesting, pigment binding protein isolated from algae (e.g. [[Spirulina]]). In Japan and China phycocyanin used as a usual coloring agent in dairy and nutritional like jellies, gums, candies, beverages and cosmetics products.<br>See also : [[Spirulina]] | Phycocyanin is light harvesting, pigment binding protein isolated from algae (e.g. [[Spirulina]]). In Japan and China phycocyanin used as a usual coloring agent in dairy and nutritional like jellies, gums, candies, beverages and cosmetics products.<br>See also : [[Spirulina]] | ||
==Health Benefits and Uses of Phycocyanin== | ==Health Benefits and Uses of Phycocyanin== | ||
| + | A major biliproteins, C-phycocyanins (C-PC) isolated from S. platensis having many therapeutic potentials like free radical scavenging activity and antioxidant, anti inflammatory and anticancer properties. | ||
* [[COVID-19]] / [[SARS]] belongs to the large family of viruses (coronaviridae), which induces disorders such as diarrhoea, fever, cough, sneezing, difficulty breathing, upper and lower respiratory tract infections and death if untreated. With the world looking for immediate relief whether through medicines or vaccines, we have taken into account the blue-green algae, Spirulina platensis, well known for its antiviral properties, in addition to its high nutritional value. More specifically, we targeted one of the important ingredients, C-Phycocyanine, for its antiviral properties, inparticular against SARS-CoV-2 via in-silicoapproaches. Initial results clearly show that C-Phycocyanine interacts with the nsp12 RoRp of SARS-CoV-2, which is the target of several drugs. | * [[COVID-19]] / [[SARS]] belongs to the large family of viruses (coronaviridae), which induces disorders such as diarrhoea, fever, cough, sneezing, difficulty breathing, upper and lower respiratory tract infections and death if untreated. With the world looking for immediate relief whether through medicines or vaccines, we have taken into account the blue-green algae, Spirulina platensis, well known for its antiviral properties, in addition to its high nutritional value. More specifically, we targeted one of the important ingredients, C-Phycocyanine, for its antiviral properties, inparticular against SARS-CoV-2 via in-silicoapproaches. Initial results clearly show that C-Phycocyanine interacts with the nsp12 RoRp of SARS-CoV-2, which is the target of several drugs. | ||
| + | * Cancer : | ||
| + | **S. platensis extracted phycocyanin exhibited antitumor activity beside squamous cell carcinoma. | ||
| + | **The enhanced phycocyanin isolated from S. platensis trigger apoptosis by CD59 proteins expression in HeLa cells line via activation of apoptosis enzymes, different caspases 2, 3, 4, 6, 8, 9, and 10. (Li et al., 2005). It has been reported that apoptosis is caused by discharge of cytochrome c from mitochondria into the cytosol in HeLa cell treated with C-phycocyanine. PC is a potent tumor chemopreventive (Li et al., 2005). | ||
| + | **Selenium-containing phycocyanin (Se-PC) isolated from S. platensis (selenium-enriched) is powerful anticarcinogenic agent on MCF-7 and A375 cells, human breast adenocarcinoma and human melanoma cells respectively | ||
| + | **The pure c-phycocyanin and polysaccharides isolated from S. platensis induce proliferation and differentiation of committed hematopoietic progenitor cell and can be reduce the probability of anemia in mice and also amplify immunity by activation of macrophage functions, production of IL-I, phagocytic process. | ||
==References== | ==References== | ||
* ''SPIRULINA C-PHYCOCYANIN INHIBITS THE NSP12 REQUIRED FOR REPLICATION OF SRAS-COV-2: A NEW IN-SILICO FINDING Kiran Raj 1, R. Ranjithkumar 2, BM Kanthesh 3 and TS Gopenath'' | * ''SPIRULINA C-PHYCOCYANIN INHIBITS THE NSP12 REQUIRED FOR REPLICATION OF SRAS-COV-2: A NEW IN-SILICO FINDING Kiran Raj 1, R. Ranjithkumar 2, BM Kanthesh 3 and TS Gopenath'' | ||
[[Category:Treatments]] | [[Category:Treatments]] | ||
Latest revision as of 11:01, 11 May 2021
Phycocyanin is light harvesting, pigment binding protein isolated from algae (e.g. Spirulina). In Japan and China phycocyanin used as a usual coloring agent in dairy and nutritional like jellies, gums, candies, beverages and cosmetics products.
See also : Spirulina
Health Benefits and Uses of Phycocyanin
A major biliproteins, C-phycocyanins (C-PC) isolated from S. platensis having many therapeutic potentials like free radical scavenging activity and antioxidant, anti inflammatory and anticancer properties.
- COVID-19 / SARS belongs to the large family of viruses (coronaviridae), which induces disorders such as diarrhoea, fever, cough, sneezing, difficulty breathing, upper and lower respiratory tract infections and death if untreated. With the world looking for immediate relief whether through medicines or vaccines, we have taken into account the blue-green algae, Spirulina platensis, well known for its antiviral properties, in addition to its high nutritional value. More specifically, we targeted one of the important ingredients, C-Phycocyanine, for its antiviral properties, inparticular against SARS-CoV-2 via in-silicoapproaches. Initial results clearly show that C-Phycocyanine interacts with the nsp12 RoRp of SARS-CoV-2, which is the target of several drugs.
- Cancer :
- S. platensis extracted phycocyanin exhibited antitumor activity beside squamous cell carcinoma.
- The enhanced phycocyanin isolated from S. platensis trigger apoptosis by CD59 proteins expression in HeLa cells line via activation of apoptosis enzymes, different caspases 2, 3, 4, 6, 8, 9, and 10. (Li et al., 2005). It has been reported that apoptosis is caused by discharge of cytochrome c from mitochondria into the cytosol in HeLa cell treated with C-phycocyanine. PC is a potent tumor chemopreventive (Li et al., 2005).
- Selenium-containing phycocyanin (Se-PC) isolated from S. platensis (selenium-enriched) is powerful anticarcinogenic agent on MCF-7 and A375 cells, human breast adenocarcinoma and human melanoma cells respectively
- The pure c-phycocyanin and polysaccharides isolated from S. platensis induce proliferation and differentiation of committed hematopoietic progenitor cell and can be reduce the probability of anemia in mice and also amplify immunity by activation of macrophage functions, production of IL-I, phagocytic process.
References
- SPIRULINA C-PHYCOCYANIN INHIBITS THE NSP12 REQUIRED FOR REPLICATION OF SRAS-COV-2: A NEW IN-SILICO FINDING Kiran Raj 1, R. Ranjithkumar 2, BM Kanthesh 3 and TS Gopenath
