Palmitoylethanolamide

Other Names : PEA, N-(2-hydroxyethyl)hexadecanamide, palmidrol, Palmidrol, N-Palmitoylethanolamine; Palmitamide MEA, Palmitylethanolamide, Hydroxyethylpalmitamide / brandnames : PeaPure, Normast, PeaVera
PEA is an endogenous fatty acid amide, produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties are known in science many decades since the first description of this compound in 1957. In 1993 the Nobel price winner professor Rita Levi-Montalcini pointed out the relevance of PEA for medicine and since then more than 300 scientific papers on PEA have been published. She also was the first person discovering the mechanism of action of PEA. She worked with PEA in its purest version.

Special Precautions of Palmitoylethanolamide

Probably due to the fact that PEA is an endogenous modulator as well as a compound in food, such as eggs and milk, no serious side effects have been reported, nor have drug–drug interactions.

Health Benefits and uses of Palmitoylethanolamide are

Palmitoylethanolamide has been demonstrated to bind to a receptor in the cell nucleus – the peroxisome proliferator–activated receptor – and performs a great variety of biological functions related to chronic and neuropathic pain and inflammation, as has been demonstrated in clinical trials. These include peripheral neuropathies such as

• diabetic neuropathy
• chemotherapy-induced peripheral neuropathy
• Carpal Tunnel Syndrome (CTS)
• Complex Regional Pain Syndrome (CRPS)
• sciatic pain (Sciatica)
• osteoarthritis (OA)
• low-Back Pain
• failed back surgery syndrome
• dental pains
• neuropathic pain in stroke and multiple sclerosis,
• chronic pelvic pain
• postherpetic neuralgia
• vaginal pains.

References

• Keppel Hesselink JM, Hekker TA- Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series